Abnormal functional network centrality in drug-naïve boys with attention-deficit/hyperactivity disorder.
Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood and is characterized by inattention, impulsivity, and hyperactivity. Observations of distributed functional abnormalities in ADHD suggest aberrant large-scale brain network connect...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 28; no. 10; pp. 1321 - 1329 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139028843&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139028843 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Oct2019 vid: 28 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139028843 139028843 143977311 139028843 10.1007/s00787-019-01297-6 139028843 ppf: 1321 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Abnormal functional network centrality in drug-naïve boys with attention-deficit/hyperactivity disorder. aug: au: Zhou, Ming Yang, Chuang Bu, Xuan Liang, Yan Lin, Haixi Hu, Xinyu Chen, Hong Wang, Meihao Huang, Xiaoqi affil: Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, 610041, Chengdu, People's Republic of China sug: subj: Neural Pathways Attention Deficit Hyperactivity Disorder Diagnosis Human Male Magnetic Resonance Imaging Methods Temporal Lobe Occipital Lobe Parietal Lobe Thalamus Cognition Male ab: Attention-deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed neurodevelopmental disorder in childhood and is characterized by inattention, impulsivity, and hyperactivity. Observations of distributed functional abnormalities in ADHD suggest aberrant large-scale brain network connectivity. However, few studies have measured the voxel-wise network centrality of boys with ADHD, which captures the functional relationships of a given voxel within the entire connectivity matrix of the brain. Here, to examine the network patterns characterizing children with ADHD, we recruited 47 boys with ADHD and 21 matched control boys who underwent resting-state functional imaging scanning in a 3.0 T MRI unit. We measured voxel-wise network centrality, indexing local functional relationships across the entire brain connectome, termed degree centrality (DC). Then, we chose the brain regions with altered DC as seeds to examine the remote functional connectivity (FC) of brain regions. We found that boys with ADHD exhibited (1) decreased centrality in the left superior temporal gyrus (STG) and increased centrality in the left superior occipital lobe (SOL) and right inferior parietal lobe (IPL); (2) decreased FC between the STG and the putamen and thalamus, which belong to the cognitive cortico-striatal–thalamic–cortical (CSTC) loop, and increased FC between the STG and medial/superior frontal gyrus within the affective CSTC loop; and (3) decreased connectivity between the SOL and cuneus within the dorsal attention network. Our results demonstrated that patients with ADHD show a connectivity-based pathophysiological process in the cognitive and affective CSTC loops and attention network. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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