Effect of Including Important Clinical Variables on Accuracy of the Lung Allocation Score for Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Rationale: Clinical variables associated with shortened survival in patients with advanced-stage cystic fibrosis (CF) are not included in the lung allocation score (LAS).Objectives: To identify variables associated with wait-list and post-transplant mortality for CF lung transplant candidates using...
| Published in: | American Journal of Respiratory & Critical Care Medicine Vol. 200; no. 8; pp. 1013 - 1022 |
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| Main Authors: | , , , , , , , |
| Format: | research Journal Article |
| Published: |
Oxford University Press / USA
10/15/2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139148877&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139148877 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1073449X 1FG jtl: American Journal of Respiratory & Critical Care Medicine issn: 1073449X maglogo: N pubinfo: dt: 10/15/2019 vid: 200 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 139148877 139148877 NLM31199166 139148877 10.1164/rccm.201902-0252OC NLM31199166 139148877 ppf: 1013 ppct: 9 formats: tig: atl: Effect of Including Important Clinical Variables on Accuracy of the Lung Allocation Score for Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. aug: au: Lehr, Carli J. Skeans, Melissa Dasenbrook, Elliott Fink, Aliza Fernandez, Gabriela Faro, Albert Valapour, Maryam Dasenbrook, Elliot C affil: Cleveland Clinic, Cleveland, Ohio. sug: subj: Algorithms Organ Procurement Standards Patient Selection Cystic Fibrosis Diagnosis Waiting Lists Lung Transplantation Standards Pulmonary Disease, Chronic Obstructive Diagnosis Cystic Fibrosis Physiopathology Aged, 80 and Over Cox Proportional Hazards Model Adult Severity of Illness Indices Female Middle Age Aged Retrospective Design Child Pulmonary Disease, Chronic Obstructive Physiopathology Young Adult Male Practice Guidelines Human Reproducibility of Results Adolescence Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged, 80 & over Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Child: 6-12 years Adolescent: 13-18 years Female Male ab: Rationale: Clinical variables associated with shortened survival in patients with advanced-stage cystic fibrosis (CF) are not included in the lung allocation score (LAS).Objectives: To identify variables associated with wait-list and post-transplant mortality for CF lung transplant candidates using a novel database and to analyze the impact of including new CF-specific variables in the LAS system.Methods: A deterministic matching algorithm identified patients from the Scientific Registry of Transplant Recipients and the Cystic Fibrosis Foundation Patient Registry. LAS wait-list and post-transplant survival models were recalculated using CF-specific variables. This multicenter, retrospective, population-based study of all lung transplant wait-list candidates aged 12 years or older from January 1, 2011, to December 31, 2014, included 9,043 patients on the lung transplant waiting list and 6,110 lung transplant recipients between 2011 and 2014, comprising 1,020 and 677 with CF, respectively.Measurements and Main Results: Measured outcomes were changes in LAS and lung allocation rank. For CF candidates, any Burkholderia sp. (hazard ratio [HR], 2.8; 95% confidence interval [CI], 1.2-6.6), 29-42 days hospitalized (HR 2.8; CI 1.3-5.9), massive hemoptysis (HR 2.1; CI 1.1-3.9), and relative drop in FEV1 ≥30% over 12 months (HR 1.7; CI 1.0-2.8) increased wait-list mortality risk; pulmonary exacerbation time 15-28 days (1.8; 1.1-2.9) increased post-transplant mortality risk. A relative drop in FEV1 ≥10% in chronic obstructive pulmonary disease (COPD) candidates was associated with increased wait-list mortality risk (HR 2.6; CI 1.2-5.4). Variability in LAS score and rank increased in patients with CF. Priority for transplant increased for COPD candidates. Access did not change for other diagnosis groups.Conclusions: Adding CF-specific variables improved discrimination among wait-listed CF candidates and benefited COPD candidates. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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