Carotid plaque composition by CT angiography in asymptomatic subjects: a head-to-head comparison to ultrasound.
Objectives: To describe carotid plaque composition by computed tomography angiography (CTA) in asymptomatic subjects and to compare this to carotid plaque assessment by ultrasound, coronary plaques by coronary CTA, and inflammatory biomarkers in plasma.Methods: Middle-aged asymptomatic men, n = 43,...
| Publicado en: | European Radiology Vol. 29; no. 11; pp. 5920 - 5932 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139163637&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139163637 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2019 vid: 29 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139163637 139163637 144097807 NLM30915562 139163637 10.1007/s00330-019-06086-y NLM30915562 139163637 ppf: 5920 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Carotid plaque composition by CT angiography in asymptomatic subjects: a head-to-head comparison to ultrasound. aug: au: Ramanathan, Ramshanker Dey, Damini Nørgaard, Bjarne L. Goeller, Markus Bjerrum, Ida S. Antulov, Ronald Diederichsen, Axel C. P. Sidelmann, Johannes J. Gram, Jørgen B. Sand, Niels Peter R. affil: Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark sug: subj: Atherosclerosis Diagnosis Carotid Artery Diseases Diagnosis Ultrasonography Methods Carotid Arteries Reproducibility of Results Aged Middle Age Cross Sectional Studies Carotid Intima-Media Thickness Male Human Female Pilot Studies Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Objectives: To describe carotid plaque composition by computed tomography angiography (CTA) in asymptomatic subjects and to compare this to carotid plaque assessment by ultrasound, coronary plaques by coronary CTA, and inflammatory biomarkers in plasma.Methods: Middle-aged asymptomatic men, n = 43, without known cardiovascular disease and diabetes were included. Plaques in coronary and carotid arteries were evaluated using CTA. Total plaque volumes and plaque composition were assessed by a validated plaque analysis software. The 60% centile cut point was used to divide the population into low or high carotid total plaque volumes. The occurrence of carotid plaques and intima-media thickness (IMT) was estimated by ultrasound.Results: Carotid plaque by ultrasound was undiagnosed in 13 of 28 participants (46%) compared to CTA. Participants having carotid plaques by ultrasound had significantly higher absolute volumes of all CTA-defined carotid plaque subtypes and a higher fraction of calcified plaque. A high carotid total plaque volume was independently associated with age (adjusted odds ratio (OR) 1.41 [95% confidence interval (CI) 1.14-1.74], p = 0.001), IMT (adjusted OR 2.26 [95% CI 1.10-4.65], p = 0.03), and D-dimer (adjusted OR 8.86 [95% CI 1.26-62.37], p = 0.03). All coronary plaque features were significantly higher in participants with a high carotid total plaque volume.Conclusion: The occurrence of carotid plaques in asymptomatic individuals is underestimated by ultrasound compared to plaque assessment by CTA. Carotid plaque composition by CTA is different in individuals with and without carotid plaques by ultrasound.Key Points: • The occurrence of carotid plaques by ultrasound was underestimated in 46% of participants who had plaques by carotid CTA. • Participants with carotid plaques by ultrasound had higher volumes of all plaque subtypes and a higher calcified plaque component as determined by carotid CTA compared to participants without carotid plaques by ultrasound. • A high carotid total plaque volume was independently associated with age, intima-media thickness, and D-dimer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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