Sparse sampling computed tomography (SpSCT) for detection of pulmonary embolism: a feasibility study.
Objectives: Evaluation of sparse sampling computed tomography (SpSCT) regarding subjective and objective image criteria for the detection of pulmonary embolism (PE) at different simulated dose levels.Methods: Computed tomography pulmonary angiography (CTPA) scans of 20 clinical patients were used to...
| Publicado en: | European Radiology Vol. 29; no. 11; pp. 5950 - 5961 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139163678&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139163678 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Nov2019 vid: 29 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139163678 139163678 NLM31073861 139163678 10.1007/s00330-019-06217-5 NLM31073861 139163678 ppf: 5950 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Sparse sampling computed tomography (SpSCT) for detection of pulmonary embolism: a feasibility study. aug: au: Sauter, Andreas P. Kopp, Felix K. Bippus, Rolf Dangelmaier, Julia Deniffel, Dominik Fingerle, Alexander A. Meurer, Felix Pfeiffer, Daniela Proksa, Roland Rummeny, Ernst J. Noël, Peter B. affil: Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany sug: subj: Pulmonary Embolism Radiation Dosage Pilot Studies Analysis of Variance Patient Safety Sensitivity and Specificity Artifacts Lung Human Funding Source ab: Objectives: Evaluation of sparse sampling computed tomography (SpSCT) regarding subjective and objective image criteria for the detection of pulmonary embolism (PE) at different simulated dose levels.Methods: Computed tomography pulmonary angiography (CTPA) scans of 20 clinical patients were used to obtain simulated low-dose scans with 100%-50%-25%-12.5%-6.3%-3.1% of the clinical dose, resulting in a total of six dose levels (DL). From these full sampling (FS) data, every second (2-SpSCT) or fourth (4-SpSCT) projection was used to obtain simulated sparse sampling scans. Each image set was evaluated by four blinded radiologists regarding subjective image criteria (artifacts, image quality) and diagnostic performance (confidence, sensitivity, specificity, accuracy, and area under the curve). Additionally, the contrast-to-noise ratio (CNR) was evaluated for objective image quality.Results: Sensitivity was 100% with 2-SpSCT and 4-SpSCT at the 25% DL and the 12.5% DL for all localizations of PE (one subgroup 98.5%). With FS, the sensitivity decreased to 90% at the 12.5% DL. 2-SpSCT and 4-SpSCT showed higher values for sensitivity, specificity, accuracy, and the area under the curve at all DL compared with FS. Subjective image quality was significantly higher for 4-SpSCT compared with FS at each dose level (p < 0.01, paired t test). Only with 4-SpSCT, all examinations were rated as showing diagnostic image quality at the 12.5% DL.Conclusions: Via SpSCT, a dose reduction down to a 12.5% dose level (corresponding to a mean effective dose of 0.38 mSv in the current study) for CTPA is possible while maintaining high image quality and full diagnostic confidence.Key Points: • With sparse sampling CT, radiation dose could be significantly reduced in clinical routine. • Sparse sampling CT is a novel hardware solution with which less projection images are acquired. • In the current study, a dose reduction of 87.5% (corresponding to a mean effective dose of 0.38 mSv) for CTPA could be achieved while maintaining excellent diagnostic performance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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