Predictors of Impaired Survival in Subjects With Long-Term Oxygen Therapy.
BACKGROUND: The need for long-term oxygen therapy (LTOT) is usually a sign of advanced disease, which could trigger advance care planning. However, LTOT is used in patients with different characteristics and multiple diagnoses beyond COPD. We studied the factors associated with survival in an unsele...
| Publicado en: | Respiratory Care Vol. 64; no. 11; pp. 1401 - 1410 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139348313&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139348313 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Nov2019 vid: 64 iid: 11 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 139348313 139348313 139348313 10.4187/respcare.06615 139348313 ppf: 1401 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Predictors of Impaired Survival in Subjects With Long-Term Oxygen Therapy. aug: au: Rantala, Heidi A. Leivo-Korpela, Sirpa Lehtimäki, Lauri Lehto, Juho T. affil: Department of Respiratory Medicine, Tampere University Hospital, Tampere, Finland sug: subj: Survival Oxygen Therapy Human Male Female Aged Aged, 80 and Over Retrospective Design Pulmonary Disease, Chronic Obstructive Lung Diseases, Interstitial Descriptive Statistics Multivariate Analysis Confidence Intervals Scales Academic Medical Centers Finland Finland Activities of Daily Living Nonparametric Statistics Mann-Whitney U Test Pearson's Correlation Coefficient Chi Square Test Fisher's Exact Test Kaplan-Meier Estimator Cox Proportional Hazards Model Data Analysis Software Funding Source Aged: 65+ years Aged, 80 & over Male Female ab: BACKGROUND: The need for long-term oxygen therapy (LTOT) is usually a sign of advanced disease, which could trigger advance care planning. However, LTOT is used in patients with different characteristics and multiple diagnoses beyond COPD. We studied the factors associated with survival in an unselected sample of subjects who started LTOT. METHODS: We conducted a retrospective study that included 195 subjects for whom LTOT was initiated in Tampere University Hospital from January 1, 2012, to December 31, 2015, and followed up until December 31, 2017. RESULTS: The most frequent diseases that caused the need for LTOT were COPD and interstitial lung diseases. Most of the subjects (69%) died during the study period; the median survival time was 2.2 y. The subjects with interstitial lung disease as a primary disease for LTOT had a shorter survival time (median 0.9 y) compared with those with COPD (median 2.4 y, P < .001). Survival was shorter in the subjects ages >75 y (median 1.4 y) compared with those who were ages ≤75 y (median 2.8 y, P = .001) and also in those who required help with daily activities (median 1.2 y) compared with those who did not (median 3.3 y, P < .001). In multivariate analysis, a diagnosis of interstitial lung disease (hazard ratio 2.1, 95% CI 1.4-3.2), Charlson comorbidity index (hazard ratio 1.26, 95% CI 1.11-1.43), and required help in activities of daily living (hazard ratio 2.1, 95% CI 1.4-3.1) were associated with impaired survival. CONCLUSIONS: The survival of the subjects who started LTOT varied greatly. The subjects with interstitial lung disease and those who required assistance with activities of daily living were at risk of dying in ~1 y, which suggested that advance care planning should be directed especially to these patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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