The use of Sodic-Salt DNA fragments in the progression of wounds healing in diabetic foot: a case control study.

Diabetic foot syndrome is a multifactorial condition, which often requires surgical intervention to heal. Ultra distal revascularisation and minor amputations are a valid therapeutic protocol for limb salvage in forefoot lesions involving the bone. Frequently, this approach implies a residual lesion...

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Publicado en:Diabetic Foot Journal Vol. 22; no. 4; pp. 12 - 17
Autores principales: Boschetti, G., Marin, M., Ninkovic, S., Whisstock, C., Anichini, R., Bruseghin, M., Manzi, M., Meloni, M., Volpe, A., Pinfi, M., Silvestri, D., Rocca, V. La, Macchi, B., Brocco, E.
Formato: research tables/charts Journal Article
Publicado: SB Communications Group, A Schofield Media Company 2019
Acceso en línea:Ver este registro en EBSCOhost
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      pub: SB Communications Group, A Schofield Media Company
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        atl: The use of Sodic-Salt DNA fragments in the progression of wounds healing in diabetic foot: a case control study.
      aug:
        au:
          Boschetti, G.
          Marin, M.
          Ninkovic, S.
          Whisstock, C.
          Anichini, R.
          Bruseghin, M.
          Manzi, M.
          Meloni, M.
          Volpe, A.
          Pinfi, M.
          Silvestri, D.
          Rocca, V. La
          Macchi, B.
          Brocco, E.
        affil: Internal Medicine Specialist, Diabetic Foot Unit, Policlinico Abano Terme, Padova
      sug:
        subj:
          Diabetic Foot Surgery
          Surgical Wound Care Methods
          Wound Healing Drug Effects
          Sodium Chloride Pharmacodynamics
          DNA Pharmacodynamics
          Treatment Outcomes Evaluation
          Human
          Male
          Female
          Aged
          Case Control Studies
          Mann-Whitney U Test
          Paired T-Tests
          Analysis of Variance
          Data Analysis Software
          Univariate Statistics
          Chi Square Test
          Cytokines Metabolism
          Nucleotides Metabolism
          Antiinfective Agents Therapeutic Use
          Antiinfective Agents, Local Therapeutic Use
          Time Factors
          Wound Infection
          Ischemia
          Hospitalization
          Karnofsky Performance Status
          Scales
          Aged: 65+ years
          Male
          Female
      ab: Diabetic foot syndrome is a multifactorial condition, which often requires surgical intervention to heal. Ultra distal revascularisation and minor amputations are a valid therapeutic protocol for limb salvage in forefoot lesions involving the bone. Frequently, this approach implies a residual lesion that can be healed with various devices, such as negative pressure wound therapy (NPWT), engineered tissues and dermal substitutes. Recently, a new sodic-salt DNA fragments (SSDF) preparation became available, which aims at exerting the tissues' reconstructive action through cytokines production and nucleotide synthesis. This study aims to evaluate the usefulness of SSDF in accelerating the healing rate of diabetic residual lesions in the foot.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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