Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance.
The saponins are a diverse class of natural products, with a broad scale distribution across different plant species. Chemically characterized as triterpenoid glycosides, they posses a 30C oxidosqualene precursor-based aglycone moiety (sapogenin), to which glycosyl residues are subsequently attached...
| Publicado en: | Protoplasma Vol. 256; no. 6; pp. 1463 - 1487 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139390315&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139390315 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0033183X 2CF jtl: Protoplasma issn: 0033183X maglogo: N pubinfo: dt: Nov2019 vid: 256 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139390315 144062031 10.1007/s00709-019-01411-0 139390315 ppf: 1463 ppct: 24 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance. aug: au: Biswas, Tanya Dwivedi, Upendra N. affil: Department of Biochemistry, University of Lucknow, 226007, Lucknow, India sug: ab: The saponins are a diverse class of natural products, with a broad scale distribution across different plant species. Chemically characterized as triterpenoid glycosides, they posses a 30C oxidosqualene precursor-based aglycone moiety (sapogenin), to which glycosyl residues are subsequently attached to yield the corresponding saponin. Based on the chemically distinct aglycone moieties, broadly, they are divided into triterpenoid saponins (dammaranes, ursanes, oleananes, lupanes, hopanes, etc.) and the sterol glycosides. This review aims to present in detail the biosynthesis patterns of the different aglycones from a common precursor and their glycosylation patterns to yield the functionally active glycoside. The review also presents recent advances in the pharmacological activities of these saponins, particularly as potent anti-neoplastic pharmacophores, antioxidants, or anti-viral/antibacterial agents. Since alternate production pedestals for these pharmacologically important triterpenes via cell and tissue cultures are an attractive option for their sustainable production, recent trends in the variety and scale of in vitro production of plant triterpenoids have also been discussed. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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