Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia.
We implemented a pharmacokinetic/pharmacodynamic (PK/PD) based optimization algorithm recommending intraoperative Remifentanil and Propofol infusion rates to minimize time to emergence and maximize the duration of analgesia in a clinical setting. This feasibility study tested the clinical acceptance...
| Publicado en: | Journal of Clinical Monitoring & Computing Vol. 33; no. 6; pp. 953 - 958 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139439719&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139439719 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13871307 OHC jtl: Journal of Clinical Monitoring & Computing issn: 13871307 maglogo: N pubinfo: dt: Dec2019 vid: 33 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139439719 139439719 144091520 NLM30868345 10.1007/s10877-019-00295-y NLM30868345 139439719 ppf: 953 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Acceptance of a propofol and remifentanil infusion dosing algorithm to optimize postoperative emergence and analgesia. aug: au: Tams, Carl Johnson, Ken Seubert, Christoph affil: Department of Anesthesiology, University of Utah, 30 N 1900 E, 84132, Salt Lake City, UT, USA sug: subj: Anesthesiology Standards Propofol Administration and Dosage Child Female Propofol Pharmacokinetics Scoliosis Surgery Postoperative Pain User-Computer Interface Pilot Studies Adolescence Anesthesia Recovery Analgesics, Opioid Administration and Dosage Decision Support Systems, Clinical Postoperative Period Computer Graphics Algorithms Pain Therapy Analgesics, Opioid Pharmacokinetics Anesthesiology Methods Young Adult Male Scales Child: 6-12 years Adolescent: 13-18 years Female Male ab: We implemented a pharmacokinetic/pharmacodynamic (PK/PD) based optimization algorithm recommending intraoperative Remifentanil and Propofol infusion rates to minimize time to emergence and maximize the duration of analgesia in a clinical setting. This feasibility study tested the clinical acceptance of the optimization algorithm's recommendations during scoliosis surgical repair for 14 patients. Anesthesiologist accepted 359/394 (91%) of the recommendations given on the basis of the optimization algorithm. While following the optimization's recommendations the anesthesiologist decreased Propofol infusions from an average of 164-135 mcg/kg/min [p = 0.002] and increased Remifentanil infusions from an average of 0.22-0.30 mcg/kg/min [p = 0.004]. The anesthesiologists appeared to accept and follow the recommendations from a PK/PD based optimization algorithm. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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