Liver CT perfusion: which is the relevant delay that reduces radiation dose and maintains diagnostic accuracy?
Objectives: High radiation dose during CT perfusion (CTp) studies contributes to prevent CTp application in daily clinical practice. This work evaluates the consequences of scan delay on perfusion parameters and provides guidelines to help reducing the radiation dose by choosing the most appropriate...
| Publicado en: | European Radiology Vol. 29; no. 12; pp. 6550 - 6559 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139479356&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139479356 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2019 vid: 29 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139479356 139479356 NLM31115620 139479356 10.1007/s00330-019-06259-9 NLM31115620 139479356 ppf: 6550 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Liver CT perfusion: which is the relevant delay that reduces radiation dose and maintains diagnostic accuracy? aug: au: Bevilacqua, Alessandro Malavasi, Silvia Vilgrain, Valérie affil: DISI (Department of Computer Science and Engineering), University of Bologna, Viale Risorgimento, 2, I-40136, Bologna, Italy sug: subj: Liver Radiation Dosage Tomography, X-Ray Computed Methods Colorectal Neoplasms Pathology Middle Age Reproducibility of Results Prospective Studies Aged Human Aged, 80 and Over Male Perfusion Imaging Female Contrast Media Adult Time Image Enhancement Methods Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Adult: 19-44 years Male Female ab: Objectives: High radiation dose during CT perfusion (CTp) studies contributes to prevent CTp application in daily clinical practice. This work evaluates the consequences of scan delay on perfusion parameters and provides guidelines to help reducing the radiation dose by choosing the most appropriate delay.Methods: Fifty-nine patients (34 men, 25 women; mean age 68 ± 12) with colorectal cancer, without underlying liver disease, underwent liver CTp, with the acquisition starting simultaneously with iodinated contrast agent injection. Blood flow (BF) and hepatic perfusion index (HPI) were computed on the acquired examinations and compared with those of the same examinations when a variable scan delay (τ) is introduced. Dose length product, CT dose index, and effective dose were also computed on original and delayed examinations.Results: Altogether, three groups of delays (τ ≤ 4 s, 5 s ≤ τ ≤ 9 s, τ ≥ 10 s) were identified, yielding increasing radiation dose saving (RDS) (RDS ≤ 9.5%, 11.9% ≤ RDS ≤ 21.4%, RDS ≥ 23.8%) and decreasing perfusion accuracy (high (τ ≤ 4 s), medium (5 s ≤ τ ≤ 9 s), low (τ ≥ 10 s)). In particular, single-input and arterial BF and HPI were more insensitive to delay as regards the absolute variations (only 1 ml/min/100 g and 1%, respectively, for τ ≤ 9 s), than portal and total BF.Conclusion: Using delays lower than 4 s does not change perfusion accuracy and conveys unnecessary dose to patients. Conversely, starting the acquisition 9 s after contrast agent injection yields a RDS of about 21%, with no significant losses in perfusion accuracy.Key Points: • Scan delays lower than 4 s do not alter perfusion accuracy and deliver an unnecessary radiation dose to patients. • Radiation dose delivered to patients can be reduced by 21.4% by introducing a 9-s scan delay, while keeping accurate perfusion values. • Using scan delays higher than 10 s, some perfusion parameters (portal and total BF) were inaccurate. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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