Assessment of hepatic steatosis by using attenuation imaging: a quantitative, easy-to-perform ultrasound technique.
Objectives: To evaluate the diagnostic performance of attenuation imaging (ATI) in the detection of hepatic steatosis compared with a histopathology gold standard.Methods: We prospectively enrolled 108 consecutive patients (35 males; median age, 54.0 years) who underwent percutaneous liver biopsy fo...
| Publicado en: | European Radiology Vol. 29; no. 12; pp. 6499 - 6508 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139479367&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139479367 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2019 vid: 29 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139479367 139479367 NLM31175413 139479367 10.1007/s00330-019-06272-y NLM31175413 139479367 ppf: 6499 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Assessment of hepatic steatosis by using attenuation imaging: a quantitative, easy-to-perform ultrasound technique. aug: au: Bae, Jae Seok Lee, Dong Ho Lee, Jae Young Kim, Haeryoung Yu, Su Jong Lee, Jeong-Hoon Cho, Eun Ju Lee, Yun Bin Han, Joon Koo Choi, Byung Ihn affil: Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea sug: subj: Ultrasonography Methods Fatty Liver Image Interpretation, Computer Assisted Methods Reproducibility of Results Liver Pathology Adult Female Fatty Liver Pathology Male Biopsy Sensitivity and Specificity Middle Age Biopsy, Needle Severity of Illness Indices Liver Prospective Studies Evaluation Research ROC Curve Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: To evaluate the diagnostic performance of attenuation imaging (ATI) in the detection of hepatic steatosis compared with a histopathology gold standard.Methods: We prospectively enrolled 108 consecutive patients (35 males; median age, 54.0 years) who underwent percutaneous liver biopsy for evaluation of diffuse liver disease between January 2018 and November 2018 in a tertiary academic center. Grayscale ultrasound examination with ATI was performed just before biopsy, and an attenuation coefficient (AC) was obtained from each patient. The degree of hepatic steatosis, fibrosis stage, and necroinflammatory activity were assessed on histopathologic examination. The significant factor associated with the AC was found by a linear regression analysis, and the diagnostic performance of the AC for the classification into each hepatic steatosis stage was evaluated by receiver operating characteristic (ROC) analysis.Results: The distribution of hepatic steatosis grade on histopathology was 53/11/22/16/6 for none/mild (< 10%)/mild (≥ 10%)/moderate/severe steatosis, respectively. The area under the ROC curve, sensitivity, specificity, and optimal cutoff AC value for detection of hepatic steatosis ranged from 0.843-0.926, 74.5-100.0%, 77.4-82.8%, and 0.635-0.745, respectively. Multivariate analysis revealed that the degree of steatosis was the only significant determinant factor for the AC.Conclusions: The AC from ATI provided good diagnostic performance in detecting the varying degrees of hepatic steatosis. The degree of steatosis was the only significant factor affecting the AC, whereas fibrosis and inflammation were not.Key Points: • Attenuation imaging (ATI) is based on two-dimensional grayscale ultrasound images that can incorporate into routine ultrasound examinations with less than 2 min of acquisition time. • ATI provided good diagnostic performance in detecting the varying degrees of hepatic steatosis with an area under the ROC curves ranging from 0.843 to 0.926, and there was no technical failure in this study indicating high applicability of this technique. • The degree of hepatic steatosis was the only significant factor affecting the result of ATI examination. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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