Predicting outcomes in non-muscle invasive (Ta/T1) bladder cancer: the role of molecular grade based on luminal/basal phenotype.
Bladder cancer tumors can be divided into two molecular subtypes referred to as luminal or basal. Each subtype may react differently to current chemotherapy or immunotherapy. Likewise, the technology required for comprehensive molecular analysis is expensive and not yet applicable for routine clinic...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 475; no. 4; pp. 445 - 456 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139479471&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139479471 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Oct2019 vid: 475 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139479471 139479471 NLM31240474 10.1007/s00428-019-02593-x NLM31240474 139479471 ppf: 445 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Predicting outcomes in non-muscle invasive (Ta/T1) bladder cancer: the role of molecular grade based on luminal/basal phenotype. aug: au: Rebola, Jorge Aguiar, Pedro Blanca, Ana Montironi, Rodolfo Cimadamore, Alessia Cheng, Liang Henriques, Vanessa Lobato-Faria, Paula Lopez-Beltran, Antonio affil: Urology Unit, Champalimaud Clinical Center, Lisbon, Portugal sug: subj: Bladder Neoplasms Pathology Bladder Neoplasms Classification Carcinoma, Transitional Cell Classification Carcinoma, Transitional Cell Pathology Middle Age Proteins Analysis Carcinoma, Transitional Cell Mortality Retrospective Design Proteins Neoplasm Grading Methods Male Female Aged, 80 and Over Bladder Neoplasms Mortality Prognosis Aged Adult Phenotype Scales Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Adult: 19-44 years Male Female ab: Bladder cancer tumors can be divided into two molecular subtypes referred to as luminal or basal. Each subtype may react differently to current chemotherapy or immunotherapy. Likewise, the technology required for comprehensive molecular analysis is expensive and not yet applicable for routine clinical diagnostics. Therefore, it has been suggested that the immunohistochemical expressions of only two markers, luminal (CK20+, CK5/6-) and basal (CK5/6+, CK20-), is sufficient to identify the molecular subtypes of bladder cancer. This would represent a molecular grade that could be used in daily practice. Molecular classification is done using immunohistochemistry to assess luminal-basal phenotype based on tissular expression of CK20 and CK5/6 as surrogate for luminal or basal subtypes, respectively. A series of 147 non-muscle-invasive bladder carcinoma cases was selected, and the tumors were divided into four subgroups based on the presence of CK20 and/or CK5/6, that is, null (CK20-, CK5/6-), mixed (CK20+, CK5/6+), basal (CK20-, CK5/6+), and luminal (CK20+, CK5/6-) categories. Survival analysis was estimated using the Kaplan-Meier method and the log-rank test. Hazard ratios were calculated by Cox multivariate analysis. The molecular grade included cases with null (n = 89), mixed (n = 6), basal (n = 20), and luminal (n = 32) phenotypes with differences in recurrence-free, progression-free and cancer-specific survival associated with molecular-grade categories in patients with low- or high-grade Ta, or high-grade T1 tumors. The multivariate analysis identified the luminal phenotype as a predictor of more aggressive neoplasms. Our findings provide a rationale to investigate luminal and basal subtypes of bladder cancer using two gene expression signatures as surrogate markers and show that non-muscle-invasive bladder carcinoma can be stratified into biologically and clinically different subgroups by using an immunohistochemical classifier. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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