Dispersion characterization of magnetic actuated needleless injections with particle image velocimetry.
Conventional needle-based approaches in intravitreal drug delivery carry needle-stick-injury risk and could scare patients (belonephobia). Alternatively, our group has explored the application of an electromagnetic needleless injector in this paper. This work aims to improve intravitreal drug delive...
| Published in: | Medical & Biological Engineering & Computing Vol. 57; no. 11; pp. 2435 - 2448 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Nov2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139479823&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139479823 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Nov2019 vid: 57 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139479823 139479823 NLM31515659 10.1007/s11517-019-02035-5 NLM31515659 139479823 ppf: 2435 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dispersion characterization of magnetic actuated needleless injections with particle image velocimetry. aug: au: Yee, Mavis Qin Ying Yeow, Bok Seng Ren, Hongliang affil: Department of BioMedical Engineering, National University of Singapore, 1 Lower Kent Ridge Rd, 119077, Singapore, Singapore sug: subj: Injections Equipment and Supplies Rheology Methods Injections Methods Needles Swine Equipment Design Drug Delivery Systems Equipment and Supplies Skin Eye Poultry Drug Delivery Systems Methods Animals Ultrasonics Phantoms, Imaging Arthritis Impact Measurement Scales Scales ab: Conventional needle-based approaches in intravitreal drug delivery carry needle-stick-injury risk and could scare patients (belonephobia). Alternatively, our group has explored the application of an electromagnetic needleless injector in this paper. This work aims to improve intravitreal drug delivery, which in the future could assist physicians with automation and benefit patients by providing a needleless approach. Electromagnetic needleless intravitreal injections lack quantification studies. We investigate the delivery properties of the needleless injector where the characterization can be used to refine the design parameters of the prototype in subsequent iterations. Experiments were performed to characterize the injectant delivered from the electromagnetic needleless injector. Penetration tests were conducted to observe the influences of various injection barriers and tissues. Ultrasonic imaging modality was explored for future applications of the prototype. The dispersion of the injectant was controllable where injection depth and distribution is dependent on the input voltage. The synthetic barriers highlighted significant energy losses for penetration (maximum velocity falls from 4.46 to 1.57 mm/s with a 0.1-mm barrier). The biological barriers were difficult to penetrate with the current prototype. Our results indicate that the current electromagnetic injector offers controllable dispersion (depth and distribution) correlated with input voltages, which should have increased injection power for use with biological tissue. Ultrasonic imaging modality produced velocity profiles comparable to the optical approach which is promising for future in vivo studies. The influences of injection barriers should be further investigated in in vivo experiments with ultrasonic imaging modalities. Graphical abstract . pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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