Epidemiology of Pseudomonas aeruginosa in cystic fibrosis in British Columbia, Canada.
Pseudomonas aeruginosa is the most common respiratory pathogen in patients with cystic fibrosis (CF), but the predominant mechanism by which it is acquired is controversial. To determine the frequency of patient-to-patient spread, we evaluated P. aeruginosa isolates from 174 patients treated at the...
| Published in: | American Journal of Respiratory & Critical Care Medicine Vol. 166; no. 7; pp. 988 - 994 |
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| Main Authors: | , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Oxford University Press / USA
2002 Oct 1
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139559464&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139559464 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1073449X 1FG jtl: American Journal of Respiratory & Critical Care Medicine issn: 1073449X maglogo: N pubinfo: dt: 2002 Oct 1 vid: 166 iid: 7 pid: 622 pub: Oxford University Press / USA artinfo: ui: 139559464 139559464 NLM12359659 139559464 10.1164/rccm.2203011 NLM12359659 139559464 ppf: 988 ppct: 6 formats: tig: atl: Epidemiology of Pseudomonas aeruginosa in cystic fibrosis in British Columbia, Canada. aug: au: Speert, David P Campbell, Maureen E Henry, Deborah A Milner, Ruth Taha, Fatma Gravelle, Anna Davidson, A George F Wong, Lawrence T K Mahenthiralingam, Eshwar affil: Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada sug: subj: Cystic Fibrosis Epidemiology Cystic Fibrosis Microbiology Pseudomonas Infant Cross Infection Microbiology Pseudomonas Infections Epidemiology Pseudomonas Infections Microbiology Electrophoresis, Gel, Pulsed-Field Human Child Welfare Pseudomonas Infections Transmission Disease Outbreaks Child British Columbia Cross Infection Epidemiology Child, Preschool Adult Adolescence Cross Infection Transmission Family Health Validation Studies Comparative Studies Evaluation Research Multicenter Studies Center for Epidemiological Studies Depression Scale Scales Infant: 1-23 months Child: 6-12 years Child, Preschool: 2-5 years Adult: 19-44 years Adolescent: 13-18 years ab: Pseudomonas aeruginosa is the most common respiratory pathogen in patients with cystic fibrosis (CF), but the predominant mechanism by which it is acquired is controversial. To determine the frequency of patient-to-patient spread, we evaluated P. aeruginosa isolates from 174 patients treated at the CF clinics in Vancouver, BC, Canada, since 1981. Multiple isolates were obtained from each patient and genetically typed by random amplified polymorphic DNA and pulsed field gel electrophoresis analyses. A total of 157 genetic types of P. aeruginosa was identified, 123 of which were unique to individual patients. A total of 34 types was shared by more than one patient; epidemiologic evidence linked these individuals only in the cases of 10 sibships and 1 pair of unrelated patients. We conclude that there is an extremely low risk in Vancouver for patients with CF to acquire P. aeruginosa from other patients. It appears that prolonged close contact, such as occurs between siblings, is necessary for patient-to-patient spread. The major source of acquisition of P. aeruginosa in CF appears to be from the environment. Considering these observations, we do not recommend segregation of patients with CF on the basis of their colonization status with P. aeruginosa. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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