Imager-4D: New Software for Viewing Dynamic PET Scans and Extracting Radiomic Parameters from PET Data.

Extensive research is currently being conducted into dynamic positron emission tomography (PET) acquisitions (including dynamic whole-body imaging) as well as extraction of radiomic features from imaging modalities. We describe a new PET viewing software known as Imager-4D that provides a facile mea...

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Bibliographic Details
Published in:Journal of Digital Imaging Vol. 32; no. 6; pp. 1071 - 1081
Main Authors: Rowe, Steven P., Solnes, Lilja B., Yin, Yafu, Kitchen, Grant, Lodge, Martin A., Karakatsanis, Nicolas A., Rahmim, Arman, Pomper, Martin G., Leal, Jeffrey P.
Format: case study diagnostic images pictorial tables/charts Journal Article
Published: Springer Nature Dec2019
Online Access:View this record in EBSCOhost
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      place: New York, New York
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        atl: Imager-4D: New Software for Viewing Dynamic PET Scans and Extracting Radiomic Parameters from PET Data.
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        au:
          Rowe, Steven P.
          Solnes, Lilja B.
          Yin, Yafu
          Kitchen, Grant
          Lodge, Martin A.
          Karakatsanis, Nicolas A.
          Rahmim, Arman
          Pomper, Martin G.
          Leal, Jeffrey P.
        affil: The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 550 N. Broadway Suite 300, 21205, Baltimore, MD, USA
      sug:
        subj:
          Software
          Radiographic Image Interpretation, Computer-Assisted
          Tomography, Emission-Computed
          Diagnostic Imaging Methods
          Radiology Information Systems
          Human
          User-Computer Interface
          Middle Age
          Female
          Colorectal Neoplasms Diagnosis
          Thyroiditis
          Algorithms
          Radiographic Image Enhancement
          Middle Aged: 45-64 years
          Female
      ab: Extensive research is currently being conducted into dynamic positron emission tomography (PET) acquisitions (including dynamic whole-body imaging) as well as extraction of radiomic features from imaging modalities. We describe a new PET viewing software known as Imager-4D that provides a facile means of viewing and analyzing dynamic PET data and obtaining associated quantitative metrics including radiomic parameters. The Imager-4D was programmed in the Java language utilizing the FX extensions. It is executable on any system for which a Java w/FX compliant virtual machine is available. The software incorporates the ability to view and analyze dynamic data acquired with different types of dynamic protocols. For image display, the program maintains a built-in library of 62 different lookup tables with monochromatic and full-color distributions. The Imager-4D provides multiple display layouts and can display fused images. Multiple methods of volume-of-interest (VOI) selection are available. Dynamic analysis features, such as image summation and full Patlak analysis, are also available. The user interface includes window width and level, blending, and zoom functionality. VOI sizes are adjustable and data from VOIs can either be displayed numerically or graphically within the software or exported. An example case of a 50-year-old woman with metastatic colorectal cancer and thyroiditis is included and demonstrates the steps for a user to obtain standard PET parameters, dynamic data, and radiomic features using selected VOIs. The Imager-4D represents a novel PET viewer that allows the user to view dynamic PET data, to derive dynamic and radiomic parameters from that data, and to combine dynamic data with radiomics ("dynomics"). The Imager-4D is available as a free download. This software has the potential to speed the adoption of advanced analysis of dynamic PET data into routine clinical use.
      pubtype: Academic Journal
      doctype:
        case study
        diagnostic images
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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