Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants.
Purpose: The aim of this study was to investigate circulating folic acid (FA) and predict circulating FA concentrations in the population related to dietary intake, vitamin concentrations, and interaction with the genetic variants involved in folate metabolism. Methods: Data were from the 'Health Su...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 8; pp. 3069 - 3078 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139586105&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139586105 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Dec2019 vid: 58 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139586105 139586105 144176573 139586105 10.1007/s00394-018-1852-5 139586105 ppf: 3069 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants. aug: au: Steluti, Josiane Reginaldo, Christina Selhub, Jacob Paul, Ligi Fisberg, Regina Mara Marchioni, Dirce Maria affil: Department of Nutrition, School of Public Health, University of São Paulo, 01246-904, São Paulo, Brazil sug: subj: Diet Folic Acid Blood Vitamin B Complex Blood Folic Acid Metabolism Polymorphism, Genetic Brazil Human Cross Sectional Studies Homocysteine Blood Vitamin B12 Blood Pyridoxine Blood DNA Analysis Linear Regression Age Factors Smoking ab: Purpose: The aim of this study was to investigate circulating folic acid (FA) and predict circulating FA concentrations in the population related to dietary intake, vitamin concentrations, and interaction with the genetic variants involved in folate metabolism. Methods: Data were from the 'Health Survey of São Paulo' a cross-sectional population-based survey, conducted in São Paulo City, Brazil. The participants (n = 750) provided fasting blood samples and food intake data. Folate, homocysteine, and B6 and B12 vitamins were assayed. DNA was isolated, and the genotypes for polymorphisms involved in folate metabolism were determined. A generalized linear model was performed to predict circulating FA concentration. Results: The circulating FA was detected in 80.0% of the population, with a median concentration of 1.6 nmol/L (IQR 0.5–2.9). The increase of circulating FA concentrations was directly associated with total folate concentration (β coeff. 1.03; 95% CI 1.02–1.04), age (β coeff. 1.01; 95% CI 1.01–1.02), current smoker (β coeff. 1.51; 95% CI 1.16–1.97), self-reported skin color (β coeff. 1.83; 95% CI 1.51–2.20), as well as interaction between folate concentration and 19-bp deletion polymorphism in DHFR (β coeff. 1.02; 95% CI 1.01–1.03), and inversely associated with vitamin B6 (β coeff. 0.99; 95% CI 0.98–0.99). Conclusions: In the current study, the presence of detectable circulating folic acid is high, and its concentration is elevated compared with other populations. Age, smoking, lower concentration of vitamin B6 and genetic variant are associated with increased levels of circulating FA. Further researches are needed to acknowledge and guarantee the safety of exposure to folic acid, especially in countries which have mandatory fortification. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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