Reliability of dynamic contrast-enhanced magnetic resonance imaging data in primary brain tumours: a comparison of Tofts and shutter speed models.
Purpose: The purpose of this study is to investigate the robustness of pharmacokinetic modelling of DCE-MRI brain tumour data and to ascertain reliable perfusion parameters through a model selection process and a stability test. Methods: DCE-MRI data of 14 patients with primary brain tumours were an...
| Publicado en: | Neuroradiology Vol. 61; no. 12; pp. 1375 - 1387 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | algorithm diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139600371&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139600371 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Dec2019 vid: 61 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139600371 139600371 143944818 139600371 10.1007/s00234-019-02265-2 139600371 ppf: 1375 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Reliability of dynamic contrast-enhanced magnetic resonance imaging data in primary brain tumours: a comparison of Tofts and shutter speed models. aug: au: Inglese, Marianna Ordidge, Katherine L. Honeyfield, Lesley Barwick, Tara D. Aboagye, Eric O. Waldman, Adam D. Grech-Sollars, Matthew affil: Department of Surgery and Cancer, GN1 Commonwealth building, Hammersmith Hospital, Imperial College London, Du Cane Road, W12 0NN, London, UK sug: subj: Magnetic Resonance Imaging Methods Neoplasm Staging Brain Neoplasms Diagnosis Models, Statistical Methods Models, Statistical Evaluation Human Models, Structural Blood-Brain Barrier Reliability ab: Purpose: The purpose of this study is to investigate the robustness of pharmacokinetic modelling of DCE-MRI brain tumour data and to ascertain reliable perfusion parameters through a model selection process and a stability test. Methods: DCE-MRI data of 14 patients with primary brain tumours were analysed using the Tofts model (TM), the extended Tofts model (ETM), the shutter speed model (SSM) and the extended shutter speed model (ESSM). A no-effect model (NEM) was implemented to assess overfitting of data by the other models. For each lesion, the Akaike Information Criteria (AIC) was used to build a 3D model selection map. The variability of each pharmacokinetic parameter extracted from this map was assessed with a noise propagation procedure, resulting in voxel-wise distributions of the coefficient of variation (CV). Results: The model selection map over all patients showed NEM had the best fit in 35.5% of voxels, followed by ETM (32%), TM (28.2%), SSM (4.3%) and ESSM (< 0.1%). In analysing the reliability of Ktrans, when considering regions with a CV < 20%, ≈ 25% of voxels were found to be stable across all patients. The remaining 75% of voxels were considered unreliable. Conclusions: The majority of studies quantifying DCE-MRI data in brain tumours only consider a single model and whole tumour statistics for the output parameters. Appropriate model selection, considering tissue biology and its effects on blood brain barrier permeability and exchange conditions, together with an analysis on the reliability and stability of the calculated parameters, is critical in processing robust brain tumour DCE-MRI data. pubtype: Academic Journal doctype: algorithm diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|