The organizing pneumonias: an update and review.
Purpose Of Review: Basic information as well as more recent concepts regarding cryptogenic organizing pneumonia and secondary forms of the disease.Recent Findings: More recently described and less well recognized illnesses associated with organizing pneumonia, such as organizing pneumonia associated...
| Publicado en: | Current Opinion in Pulmonary Medicine Vol. 11; no. 5; pp. 422 - 431 |
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| Autores principales: | , |
| Formato: | research Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Sep2005
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139615828&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139615828 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10705287 IQZ jtl: Current Opinion in Pulmonary Medicine issn: 10705287 maglogo: N pubinfo: dt: Sep2005 vid: 11 iid: 5 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 139615828 139615828 NLM16093817 139615828 10.1097/01.mcp.0000175521.41729.07 NLM16093817 139615828 ppf: 422 ppct: 9 formats: tig: atl: The organizing pneumonias: an update and review. aug: au: Schlesinger, Cory Koss, Michael N affil: Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA sug: subj: Cryptogenic Organizing Pneumonia Diagnosis Cryptogenic Organizing Pneumonia Pathology Cryptogenic Organizing Pneumonia Therapy Organizing Pneumonia Diagnosis Organizing Pneumonia Pathology Organizing Pneumonia Therapy Human Granulation Tissue Pathology Disease Progression Glucocorticoids Therapeutic Use Nomenclature Bronchi Pathology Inflammation Pathology ab: Purpose Of Review: Basic information as well as more recent concepts regarding cryptogenic organizing pneumonia and secondary forms of the disease.Recent Findings: More recently described and less well recognized illnesses associated with organizing pneumonia, such as organizing pneumonia associated with radiation, are enumerated. In vitro studies from separate laboratories are integrated to create a proposed model of the pathogenesis and repair mechanisms that occur in organizing pneumonias. Using current criteria, we note other interstitial lung processes, in addition to organizing pneumonia, are present in some earlier reports.Summary: Cryptogenic organizing pneumonia has been reported to respond to corticosteroids with clinico-radiographic resolution in 70-80% of cases. Treatment duration is lengthy, and despite this, recurrences and late recurrences are common. Rapidly progressive, steroid resistant and poor prognostic forms of organizing pneumonia have been described and have been reported more frequently with secondary organizing pneumonia. Since other histologic interstitial patterns often coexist with organizing pneumonia, tissue sampling error or an incorrect morphologic diagnosis can be the reason for aggressive clinical behavior. Steroid nonresponsive patients have been treated with secondary non-steroidal agents. Good clinical outcomes have been reported. Inhaled antigens stimulate GM-CSF-mediated airway inflammation in organizing pneumonia. Repair requires the following: granulation tissue, upon which re-epithelialization occurs; a favorable stromal ratio of matrix metalloproteinase to tissue inhibitors of metalloproteinase; concurrent resolution of inflammation; and stromal fibroblast ingestion of collagen produced earlier in repair, reversing the initial fibrosis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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