Prescription of High-Dose Opioids Among People Living with HIV in British Columbia, Canada.
People living with HIV (PLHIV) often experience pain for which opioid medications may be prescribed. Thus, these individuals are particularly vulnerable to opioid-related harms, including overdose, misuse, and addiction, particularly when prescribed at high doses. We used a comprehensive linked popu...
| Publicado en: | AIDS & Behavior Vol. 23; no. 12; pp. 3331 - 3340 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139632715&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139632715 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10907165 G1T jtl: AIDS & Behavior issn: 10907165 maglogo: N pubinfo: dt: Dec2019 vid: 23 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139632715 139632715 144178817 139632715 10.1007/s10461-019-02589-3 139632715 ppf: 3331 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prescription of High-Dose Opioids Among People Living with HIV in British Columbia, Canada. aug: au: Clark, Jessica Fairbairn, Nadia Nolan, Seonaid Li, Tian Wu, Anthony Barrios, Rolando Montaner, Julio Ti, Lianping the STOP HIV/AIDS in BC Study Group Daly, Patty Gustafson, Reka Kendall, Perry R. W. Panessa, Ciro Heath, Kate Hogg, Robert S. Montaner, Julio S. G. affil: Department of Medicine, University of British Columbia, 2775 Laurel Street, V5Z 1M9, Vancouver, BC, Canada sug: subj: Analgesics, Opioid Administration and Dosage Prescriptions, Drug HIV-Positive Persons British Columbia Prescribing Patterns British Columbia Analgesics, Opioid Adverse Effects Overdose Risk Factors Odds Ratio Confidence Intervals Morphine Antianxiety Agents, Benzodiazepine Substance Use Disorders Risk Assessment Attitude to AIDS Human ab: People living with HIV (PLHIV) often experience pain for which opioid medications may be prescribed. Thus, these individuals are particularly vulnerable to opioid-related harms, including overdose, misuse, and addiction, particularly when prescribed at high doses. We used a comprehensive linked population-level database of PLHIV in British Columbia (BC) to identify demographic and clinical characteristics associated with being prescribed any high-dose opioid analgesic, defined as > 90 daily morphine milligram equivalents (MME/day). Among PLHIV who were prescribed opioids between 1996 and 2015 (n = 10,780), 28.2% received prescriptions of > 90 MME/day at least once during the study period. Factors positively associated with being prescribed high-dose opioid analgesics included: co-prescription of benzodiazepines (adjusted odds ratio [AOR] = 1.14; 95% confidence interval 1.11–1.17); presence of an AIDS-defining illness (ADI; AOR = 1.78; 95% CI 1.57–2.02); seen by an HIV specialist (AOR = 1.24; 95% CI 1.20–1.29); substance use disorder (AOR = 1.46; 95% CI 1.25–1.71); and more recent calendar year (AOR = 1.05; 95% CI 1.04–1.06). Given the known risks associated with high-dose opioid prescribing, future research efforts should focus on the clinical indication and outcomes associated with these prescribing practices. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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