Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma.
Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal serrated lesion. We here report a sigmoid colon cancer derived from SuSA, which exhibited aggressive clinical behavior. Endoscopically, the tumor appeared as a superficial elevated lesion with a large nodule. Histolog...
| Publicado en: | Virchows Archiv: European Journal of Pathology Vol. 475; no. 5; pp. 659 - 664 |
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| Autores principales: | , , , , , , |
| Formato: | case study pictorial tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139722586&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139722586 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09456317 O1Z jtl: Virchows Archiv: European Journal of Pathology issn: 09456317 maglogo: N pubinfo: dt: Nov2019 vid: 475 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139722586 139722586 144015360 NLM31209633 139722586 10.1007/s00428-019-02604-x NLM31209633 139722586 ppf: 659 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Identification of a novel PRR15L-RSPO2 fusion transcript in a sigmoid colon cancer derived from superficially serrated adenoma. aug: au: Mizuguchi, Yasuhiko Sakamoto, Taku Hashimoto, Taiki Tsukamoto, Shunsuke Iwasa, Satoru Saito, Yutaka Sekine, Shigeki affil: Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan sug: subj: Sigmoid Neoplasms Adenocarcinoma Proteins Adenoma Intercellular Signaling Peptides and Proteins Middle Age Adenocarcinoma Pathology Colonic Polyps Pathology Neoplastic Processes Mutation Neoplasm Metastasis Sigmoid Neoplasms Diagnosis Genes Sigmoid Neoplasms Pathology Lymph Nodes Pathology Fatal Outcome Adenoma Pathology Adenoma Diagnosis Female Adenocarcinoma Diagnosis Scales Middle Aged: 45-64 years Female ab: Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal serrated lesion. We here report a sigmoid colon cancer derived from SuSA, which exhibited aggressive clinical behavior. Endoscopically, the tumor appeared as a superficial elevated lesion with a large nodule. Histological examination of the surgically resected material showed tubular adenocarcinoma associated with SuSA. Although tumor invasion was limited to the submucosal layer, lymph node and extranodal metastases were detected. The patient subsequently developed peritoneal metastases and died 15 months after surgery. Molecular analyses identified a KRAS mutation and a novel PRR15L-RSPO2 fusion, which retains the entire coding region of RSPO2, in both SuSA and adenocarcinoma components. The present study demonstrates the malignant potential of SuSA and expands the spectrum of RSPO fusions in colorectal neoplasms. pubtype: Academic Journal doctype: case study pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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