Efficacy of microsurgery in combined with topical-PDT in treating recurrent respiratory papillomatosis: compare JORRP with AORRP.
Background: Recurrent respiratory papillomatosis (RRP) remains a challenging and frustrating disease to treat. Objective: To explore the efficacy of microsurgery in combined with Topical-PDT in treating recurrent respiratory papillomatosis. Materials and methods: Fifty patients with RRP were treated...
| Publicado en: | Acta Oto-Laryngologica Vol. 139; no. 12; pp. 1133 - 1140 |
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| Autores principales: | , , , , , , , , |
| Formato: | clinical trial pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139742022&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139742022 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Dec2019 vid: 139 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 139742022 139742022 139742022 10.1080/00016489.2019.1667530 139742022 ppf: 1133 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Efficacy of microsurgery in combined with topical-PDT in treating recurrent respiratory papillomatosis: compare JORRP with AORRP. aug: au: Yang, Shuzhi Zhou, Chengyong Sun, Baochun Wang, Feng Han, Zeli Zhang, Hongjia Han, Jiahong Shen, Yao Zhang, Jiao affil: Department of Otolaryngology, The 4th Medical Center of the PLA General Hospital, Beijing, China sug: subj: Microsurgery Photodynamic Therapy Recurrence Laryngeal Neoplasms Therapy Laryngeal Neoplasms Therapy Treatment Outcomes Human Clinical Trials Papilloma Retrospective Design Age Factors Descriptive Statistics Disease Remission Tracheostomy Pearson's Correlation Coefficient Infant Child, Preschool Child Adolescence Adult Middle Age Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years ab: Background: Recurrent respiratory papillomatosis (RRP) remains a challenging and frustrating disease to treat. Objective: To explore the efficacy of microsurgery in combined with Topical-PDT in treating recurrent respiratory papillomatosis. Materials and methods: Fifty patients with RRP were treated with microsurgery in combined with Topical-PDT. Medical document of each patient was retrospectively reviewed. Detailed clinical information, metrics of clinical course, and current results were evaluated. Results: Juvenile onset RRP (JORRP) might experience a more aggressive course than AORRP (adult onset RRP) with higher Derkay score (p <.01) and higher operation frequency per year (p <.01). Microsurgical excision combined with Topical-PDT every 25 days achieved "remission" of disease in 78% of patients, "clearance" of disease in 52%, and "Cured" in two patients. Each patient who achieved "remission" of disease, performed 6.82 ± 3.39 operations, and continued 8.93 ± 7.03 months of treatment duration. No statistically differences were found in these two aspects between JORRP and AORRP. A negative correlation between tracheotomy and the efficacy of microsurgery in combined with Topical-PDT was found (p =.025, Pearson's r = –0.3). Conclusions and significance: Microsurgery in combined with Topical-PDT might be a powerful method to treat RRP. Tracheotomy is a negative factor for this therapy. 背景：反复性呼吸道乳头状瘤病（RRP）仍然是一种相当难治且令人沮丧的疾病。 目的：探讨显微外科手术结合局部PDT治疗复发性呼吸道乳头状瘤的疗效。 材料和方法：50例RRP患者接受显微外科手术结合局部PDT治疗。回顾性审查了每位患者的医疗记录, 评估了详细的临床信息、临床病程指标和当前结果。 结果：少年发病RRP（JORRP）可能比成人发病RRP （AORRP）具有更急势的过程, Derkay评分更高（p <.01）, 每年的手术频率也更高（p <.01）。每25天进行显微手术切除联合局部-PDT, 在78％的患者中实现病情"缓解", 52％的病情"清除", 以及两名患者的"治愈"。每位达到疾病"缓解"状态的患者均进行了6.82 ± 3.33个月的手术, 并持续了8.93 ± 7.03个月的治疗时间。JORRP和AORRP在这两个方面均未发现统计学差异。气管切开术与显微外科手术结合局部PDT的效果呈负相关（p =.025, 相关系数r =–0.3）。 结论与意义：显微外科联合局部PDT可能是治疗RRP的有效方法。气管切开术是该疗法的负因素。 pubtype: Academic Journal doctype: clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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