Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia.
Purpose: Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ). The purpose of this study was to evaluate health-related quality of life...
| Publicado en: | Quality of Life Research Vol. 28; no. 12; pp. 3303 - 3313 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139744861&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139744861 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Dec2019 vid: 28 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139744861 139744861 NLM31435866 10.1007/s11136-019-02269-8 NLM31435866 139744861 ppf: 3303 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effect of tardive dyskinesia on quality of life in patients with bipolar disorder, major depressive disorder, and schizophrenia. aug: au: McEvoy, Joseph Gandhi, Sanjay K. Rizio, Avery A. Maher, Stephen Kosinski, Mark Bjorner, Jakob Bue Carroll, Benjamin affil: Medical College of Georgia, Augusta, GA, USA sug: subj: Antipsychotic Agents Adverse Effects Depression Drug Therapy Bipolar Disorder Drug Therapy Quality of Life Psychosocial Factors Schizophrenia Drug Therapy Male Adult Middle Age Depression Psychosocial Factors Bipolar Disorder Psychosocial Factors Female Cross Sectional Studies Psychology Questionnaires Scales Self-Rating Depression Scale Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: Tardive dyskinesia (TD) is a common but serious hyperkinetic movement disorder and side effect of antipsychotic medications used to treat bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ). The purpose of this study was to evaluate health-related quality of life (HRQoL) in a population with diagnoses for BD, MDD, or SZ by comparing patients with TD (n = 197) with those without TD (n = 219). HRQoL in each group was also compared with HRQoL of the general population.Methods: This study employed a cross-sectional web-based survey. HRQoL was assessed by four instruments: the SF-12 Health Survey, Version 2 (SF-12v2), the Quality of Life Enjoyment and Satisfaction Questionnaire, Short Form (Q-LES-Q-SF), the Social Withdrawal subscale of the Internalized Stigma of Mental Illness Scale (SW-ISMI); and two questions on movement disorders.Results: Patients with TD had significantly worse HRQoL and social withdrawal than those without. The differences were more pronounced for physical HRQoL domains than for mental health domains. Patients with more-severe TD, assessed through either self-rating or clinician rating, experienced significantly worse HRQoL than did those with less-severe TD. The impact of TD was substantially greater in patients with SZ than in those with BD or MDD. Compared with the general population, patients with BD, MDD, or SZ experienced significantly worse HRQoL regardless of TD status, although this deficit in HRQoL was greater among those with TD.Conclusions: The presence of TD is associated with worse HRQoL and social withdrawal. The most severe impact of TD is on physical aspects of patients' HRQoL. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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