The Effect of Acutely Administered Propofol on Forced Swim Test Outcomes in Mice.
Objective: Propofol (2,6-diisopropylphenol) is a gamma-aminobutyric acid type A agonist intravenous anesthetic agent used in outpatient settings. Based on anecdotal reports of improved mood in humans following propofol-induced anesthesia, the impact of acute propofol treatment alone or in combinatio...
| Publicado en: | Innovations in Clinical Neuroscience Vol. 16; no. 9/10; pp. 22 - 27 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Matrix Medical Communications, LLC
Sep/Oct2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139807197&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139807197 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 21588333 DAD5 jtl: Innovations in Clinical Neuroscience issn: 21588333 maglogo: N pubinfo: dt: Sep/Oct2019 vid: 16 iid: 9/10 pid: 33670 pub: Matrix Medical Communications, LLC place: West Chester, Pennsylvania artinfo: ui: 139807197 139807197 139807197 139807197 ppf: 22 ppct: 5 formats: fmt: @attributes: type: P tig: atl: The Effect of Acutely Administered Propofol on Forced Swim Test Outcomes in Mice. aug: au: DANIEL, DAVID G. DANIEL, NOAH G. DANIEL, DONALD T. FLYNN, LAURA COPELAND ALLEN, MICHAEL H. affil: Bioniche Global Development, LLC in McLean, Virginia sug: subj: Drug Therapy, Combination Propofol Pharmacodynamics Fluoxetine Pharmacodynamics Behavior, Animal Drug Effects Swimming Task Performance and Analysis Depression Drug Therapy Animal Studies Mice Administration, Intraperitoneal Propofol Administration and Dosage Fluoxetine Administration and Dosage Normal Saline Administration and Dosage Physical Mobility Drug Effects Physical Mobility Evaluation Videorecording Software One-Way Analysis of Variance Hardiness Stress, Psychological Drug Therapy ab: Objective: Propofol (2,6-diisopropylphenol) is a gamma-aminobutyric acid type A agonist intravenous anesthetic agent used in outpatient settings. Based on anecdotal reports of improved mood in humans following propofol-induced anesthesia, the impact of acute propofol treatment alone or in combination with subchronic fluoxetine dosing was tested on forced swim test (FST) performance. Design: Seventy-two adult male mice (C57/BL6, CRL-provided) were pretreated daily with saline or fluoxetine (20 mg/kg, intraperitoneally) (21 days for cohort 1; 24 days for cohort 2). At 24 hours after the last pretreatment injection, the mice received saline or propofol (35 or 50 mg/kg, intraperitoneally). Then, 45 minutes later, the mice underwent a five-minute FST. Immobility time was quantified and evaluated with a custom video-analysis software program. Results: A one-way analysis of variance indicated statistically significant effects of propofol on immobility time in cohorts 1 and 2. A comparison performed using Dunnett's method revealed that propofol 50 mg/kg (p < 0.05) but not 35 mg/kg (p = not significant) reduced immobility time as compared with in the saline--saline control group (difference between means of 38.42 and 16.46 seconds, respectively). Conclusion: In comparison with saline, propofol significantly decreased immobility time during the FST, which models depression and resilience to stress. Our preclinical results are consistent with a small open-label study of propofol used in treatment-resistant depression recently reported by Mickey BJ, White AT, Arp AM, et al (2018). Further investigation of propofol regarding its potential antidepressant effects seems warranted. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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