Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress.

Background: Mutations in genes associated with homologous recombination (HR) increase an individual's risk of developing triple-negative breast cancer (TNBC). Although known for their role in repairing dsDNA breaks, HR repair elements also stabilize and restart stalled replication forks. Essential t...

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Bibliographic Details

Published in:	Breast Cancer Research Vol. 21; no. 1
Main Authors:	Pearson, Scott J., Elswood, Jessica, Barhoumi, Rola, Ming-Whitfield, Brittini, Rijnkels, Monique, Porter, Weston W.
Format:	Journal Article
Published:	BioMed Central 11/27/2019
Online Access:	View this record in EBSCOhost