Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis.
IL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto's thyroiditis (HT) is not clear. In the present study, we found that, in tissues from HT patients, most of the follicular epithelial cells were posit...
| Publicado en: | Histochemistry & Cell Biology Vol. 152; no. 6; pp. 467 - 474 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139882869&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139882869 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09486143 NQI jtl: Histochemistry & Cell Biology issn: 09486143 maglogo: N pubinfo: dt: Dec2019 vid: 152 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 139882869 10.1007/s00418-019-01820-5 139882869 ppf: 467 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis. aug: au: Ren, Cui-Ping Sun, Li Liu, Feng-Chun Zuo, Chun-Lin Liu, Miao Gao, Wenda Shen, Ji-Jia affil: Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Pathogen Biology, Anhui Provincial Laboratory of Zoonoses, Laboratory of Tropical and Parasitic Diseases Control, School of Basic Medical Sciences, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People's Republic of China sug: ab: IL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto's thyroiditis (HT) is not clear. In the present study, we found that, in tissues from HT patients, most of the follicular epithelial cells were positive for both IL-37 and single Ig IL-1-related receptor (SIGIRR) by immunohistochemical staining, while the infiltrating lymphocytes and other inflammatory cells hardly expressed any. Meanwhile, mRNA expression levels of IL-37 in peripheral blood mononuclear cells (PBMC) of HT patients were significantly higher than those in normal controls measured by quantitative real-time PCR. Finally, we studied the possible role of IL-37 in IFN-γ-stimulated rat FRTL-5 cells. The results showed that IL-1β, TNF-α, and MCP-1 mRNA levels were significantly decreased, while the expression of IL-4 mRNA was dramatically up-regulated in IFN-γ-stimulated rat thyroid cell line FRTL-5 pre-treated with IL-37. The current study, for the first time, demonstrated that the IL-37 network is involved in Hashimoto's thyroiditis, and IL-37 signaling pathway may ameliorate the excessive autoimmune responses in this chronic lymphocytic thyroiditis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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