Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system.
Background: As the prevalence of diabetes mellitus increases in the population, the exposure to antidiabetic drugs (ADDs) during pregnancies is expected to grow, as has been seen over the last decade. The objective of this study was to estimate the prevalence of ADD use during pregnancy among women...
| Publicado en: | BMC Pregnancy & Childbirth Vol. 19; no. 1; pp. 441 - 442 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
11/27/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139920078&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139920078 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712393 1CII jtl: BMC Pregnancy & Childbirth issn: 14712393 maglogo: N pubinfo: dt: 11/27/2019 vid: 19 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 139920078 139920078 NLM31775682 10.1186/s12884-019-2609-8 NLM31775682 139920078 ppf: 441 ppct: 1 formats: tig: atl: Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system. aug: au: Mott, Katrina Reichman, Marsha E Toh, Sengwee Kieswetter, Caren Haffenreffer, Katherine Andrade, Susan E affil: Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, USA sug: subj: Diabetes Mellitus Drug Therapy Diabetes Mellitus, Gestational Drug Therapy Pregnancy in Diabetes Drug Therapy Hypoglycemic Agents Therapeutic Use Pregnancy Outcomes Young Adult Insulin Therapeutic Use Pregnancy United States Middle Age Female Adolescence Resource Databases Child Prescriptions, Drug Statistics and Numerical Data Glyburide Therapeutic Use Adult Interview Guides Questionnaires Middle Aged: 45-64 years Adolescent: 13-18 years Child: 6-12 years Adult: 19-44 years Female ab: Background: As the prevalence of diabetes mellitus increases in the population, the exposure to antidiabetic drugs (ADDs) during pregnancies is expected to grow, as has been seen over the last decade. The objective of this study was to estimate the prevalence of ADD use during pregnancy among women in the Mini-Sentinel Distributed Database (MSDD) who delivered a liveborn infant.Methods: We identified qualifying livebirth pregnancies among women aged 10 to 54 years in the MSDD from 2001 to 2013. ADD use was estimated using outpatient pharmacy dispensing claims and days-supplied among three cohorts: all livebirth pregnancies, pregnancies among women with pre-existing diabetes, and pregnancies among women without prior ADD use.Results: Among the 1.9 million pregnancies in the MSDD that resulted in a livebirth from 2001 to 2013, 4.4% were exposed to an ADD. Of the 15,606 pregnancies (0.8%) with pre-existing diabetes, 92.8% were also exposed during the pregnancy period. The most commonly used product in these pregnancies was insulin (75.6% of pregnancies). In contrast, in pregnancies of women without prior ADD use, the most commonly used products were glyburide and insulin, and most of these users were diagnosed with gestational diabetes.Conclusions: Patterns of ADD use during pregnancy described here, along with changes in disease incidence and management, highlight the importance of continuing surveillance of ADD utilization patterns and examining the safety and effectiveness of these products in pregnancy. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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