Validation of MR-Based Attenuation Correction of a Newly Released Whole-Body Simultaneous PET/MR System.
The aim of this study was to validate quantitative performance of a newly released simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) scanner, by using MR-based attenuation correction (MRAC), both in phantom study and in patient study. PET/MRI image uniformities of a ph...
| Publicado en: | BioMed Research International pp. 1 - 11 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/28/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=139934823&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 139934823 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/28/2019 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 139934823 139934823 139934823 10.1155/2019/8213215 139934823 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Validation of MR-Based Attenuation Correction of a Newly Released Whole-Body Simultaneous PET/MR System. aug: au: Liu, Guobing Cao, Tuoyu Hu, Lingzhi Zheng, Jiaxu Pang, Lifang Hu, Pengcheng Gu, Yushen Shi, Hongcheng affil: Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China sug: subj: Tomography, Emission-Computed Methods Magnetic Resonance Imaging Methods Image Interpretation, Computer Assisted Methods Artifacts Phantoms, Imaging Sensitivity and Specificity Human Fludeoxyglucose F 18 Diagnostic Use Tomography, X-Ray Computed Methods Liver Radiography Lung Radiography Connective Tissue Diseases Radiography Bone Diseases Radiography ab: The aim of this study was to validate quantitative performance of a newly released simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) scanner, by using MR-based attenuation correction (MRAC), both in phantom study and in patient study. PET/MRI image uniformities of a phantom under different hardware configurations were tested and compared. Thirty patients were examined with 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) PET/computed tomography (CT) and subsequent PET/MRI. PET images from PET/MRI were corrected with MRAC (PETMR), CT-based attenuation maps (μ-maps, PETCT), and segmented CT μ-maps (PETCTSeg) derived from PET/CT. Standardized uptake values (SUVs) were compared among the 3 sets of PET in main organs (bone, liver and lung) and in 52 FDG-avid lesions, including soft-tissue lesions and bone lesions. The result showed that PET imaging uniformities of PET/MRI under different configurations were good (<8.8%). The SUV differences among the 3 sets of PET varied with organs and lesion types. In detail, the mean relative differences of SUV between PETMR and PETCT were as follows: −18.8%, bone (SUVmean); −8.0%, liver (SUVmean); −12.2%, lung (SUVmean); −18.1%, bone lesions (SUVmean); −13.3%, bone lesions (SUVmax); −8.2%, soft-tissue lesions (SUVmean); and −7.3%, soft-tissue lesions (SUVmax). The mean relative differences between PETMR and PETCTSeg were as follows: −19.0%, bone (SUVmean); −3.5%, liver (SUVmean); −3.3%, lung (SUVmean); −19.3%, bone lesions (SUVmean); −17.5%, bone lesions (SUVmax); −5.5%, soft-tissue lesions (SUVmean); and −4.4%, soft-tissue lesions (SUVmax). The differences of SUV between PETMR and PETCT were larger than those between PETMR and PETCTSeg, in both soft tissue and soft-tissue lesions (P<0.001), but not in bone or bone lesions. In conclusion, MRAC in the newly released PET/MR system is accurate in most tissues, with SUV deviations being generally less than 10%, compared to PET/CT. In bone, however, underestimations can be substantial, which may be partially attributed to segmentation of the MR-based μ-maps. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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