No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis.
<bold>Objective: </bold>Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have...
| Publicado en: | American Journal of Psychiatry Vol. 176; no. 12; pp. 1039 - 1050 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | journal article |
| Publicado: |
American Psychiatric Publishing, Inc.
Dec2019
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=139978994&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 139978994 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 0002953X API jtl: American Journal of Psychiatry issn: 0002953X maglogo: N pubinfo: dt: Dec2019 vid: 176 iid: 12 pid: 37323 pub: American Psychiatric Publishing, Inc. artinfo: ui: 139978994 10.1176/appi.ajp.2019.18101144 ppf: 1039 ppct: 11 formats: tig: atl: No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis. aug: au: de Kovel, Carolien G.F. Aftanas, Lyubomir Aleman, André Alexander-Bloch, Aaron F. Baune, Bernhard T. Brack, Ivan Bülow, Robin Busatto Filho, Geraldo Carballedo, Angela Connolly, Colm G. Cullen, Kathryn R. Dannlowski, Udo Davey, Christopher G. Dima, Danai Dohm, Katharina Erwin-Grabner, Tracy Frodl, Thomas Fu, Cynthia H.Y. Hall, Geoffrey B. Glahn, David C. affil: The Department of Language and Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands (de Kovel, Francks) su: Mental depression Case-control method Brain function localization Brain anatomy Consortia Riddles Databases Evaluation research Research funding Magnetic resonance imaging Research methodology Research Neuroradiology Cerebral dominance Comparative studies sug: subj: Mental depression Case-control method Diagnostic Imaging Centers Brain function localization Brain anatomy Consortia Riddles Databases Evaluation research Research funding Magnetic resonance imaging Research methodology Research Neuroradiology Cerebral dominance Comparative studies keyword: Laterality Left-Right Asymmetry Major Depressive Disorder MRI Laterality Left-Right Asymmetry Major Depressive Disorder MRI ab: <bold>Objective: </bold>Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects.<bold>Methods: </bold>The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T1-weighted MRI data were processed with a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1.<bold>Results: </bold>The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset.<bold>Conclusions: </bold>Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases. pubtype: Academic Journal doctype: journal article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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