Developmental Plasticity and Cellular Reprogramming in Caenorhabditis elegans.
While Caenorhabditis elegans was originally regarded as a model for investigating determinate developmental programs, landmark studies have subsequently shown that the largely invariant pattern of development in the animal does not reflect irreversibility in rigidly fixed cell fates. Rather, cells a...
| Publicado en: | Genetics Vol. 213; no. 3; pp. 723 - 758 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140032723&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140032723 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00166731 GNT jtl: Genetics issn: 00166731 maglogo: N pubinfo: dt: Nov2019 vid: 213 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 140032723 10.1534/genetics.119.302333 140032723 ppf: 723 ppct: 35 formats: tig: atl: Developmental Plasticity and Cellular Reprogramming in Caenorhabditis elegans. aug: au: Rothman, Joel Jarriault, Sophie affil: Department of MCD Biology and Neuroscience Research Institute, University of California, Santa Barbara, California 93111 sug: subj: Nematodes Analysis Cell Physiology Evaluation Cell Differentiation Evaluation Mutation Gene Expression Fetal Development Stem Cells ab: While Caenorhabditis elegans was originally regarded as a model for investigating determinate developmental programs, landmark studies have subsequently shown that the largely invariant pattern of development in the animal does not reflect irreversibility in rigidly fixed cell fates. Rather, cells at all stages of development, in both the soma and germline, have been shown to be capable of changing their fates through mutation or forced expression of fate-determining factors, as well as during the normal course of development. In this chapter, we review the basis for natural and induced cellular plasticity in C. elegans. We describe the events that progressively restrict cellular differentiation during embryogenesis, starting with the multipotency-to-commitment transition (MCT) and subsequently through postembryonic development of the animal, and consider the range of molecular processes, including transcriptional and translational control systems, that contribute to cellular plasticity. These findings in the worm are discussed in the context of both classical and recent studies of cellular plasticity in vertebrate systems. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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