Improving rare disease classification using imperfect knowledge graph.
Background: Accurately recognizing rare diseases based on symptom description is an important task in patient triage, early risk stratification, and target therapies. However, due to the very nature of rare diseases, the lack of historical data poses a great challenge to machine learning-based appro...
| Publicado en: | BMC Medical Informatics & Decision Making Vol. 19 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
12/5/2019 Supplement 5
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140156071&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140156071 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726947 1CI0 jtl: BMC Medical Informatics & Decision Making issn: 14726947 maglogo: N pubinfo: dt: 12/5/2019 Supplement 5 vid: 19 pid: 24147 pub: BioMed Central artinfo: ui: 140156071 140156071 NLM31801534 140156071 10.1186/s12911-019-0938-1 NLM31801534 140156071 ppct: 1 formats: tig: atl: Improving rare disease classification using imperfect knowledge graph. aug: au: Li, Xuedong Wang, Yue Wang, Dongwu Yuan, Walter Peng, Dezhong Mei, Qiaozhu affil: College of Computer Science, Sichuan University, Chengdu, China sug: subj: Disease Attributes Classification Algorithms Human Information Science Triage Validation Studies Comparative Studies Evaluation Research Multicenter Studies ab: Background: Accurately recognizing rare diseases based on symptom description is an important task in patient triage, early risk stratification, and target therapies. However, due to the very nature of rare diseases, the lack of historical data poses a great challenge to machine learning-based approaches. On the other hand, medical knowledge in automatically constructed knowledge graphs (KGs) has the potential to compensate the lack of labeled training examples. This work aims to develop a rare disease classification algorithm that makes effective use of a knowledge graph, even when the graph is imperfect.Method: We develop a text classification algorithm that represents a document as a combination of a "bag of words" and a "bag of knowledge terms," where a "knowledge term" is a term shared between the document and the subgraph of KG relevant to the disease classification task. We use two Chinese disease diagnosis corpora to evaluate the algorithm. The first one, HaoDaiFu, contains 51,374 chief complaints categorized into 805 diseases. The second data set, ChinaRe, contains 86,663 patient descriptions categorized into 44 disease categories.Results: On the two evaluation data sets, the proposed algorithm delivers robust performance and outperforms a wide range of baselines, including resampling, deep learning, and feature selection approaches. Both classification-based metric (macro-averaged F1 score) and ranking-based metric (mean reciprocal rank) are used in evaluation.Conclusion: Medical knowledge in large-scale knowledge graphs can be effectively leveraged to improve rare diseases classification models, even when the knowledge graph is incomplete. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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