Different Characteristics and Heritabilities of Alcohol Use Disorder Classes: A Population-Based Swedish Study.
Aims The aims of the present study are to identify alcohol use disorder (AUD) classes among a population-based Swedish sample, determine if these classes differ by variables known to be associated with AUD and determine whether some AUD classes have stronger genetic influences than others. Methods A...
| Publicado en: | Alcohol & Alcoholism Vol. 54; no. 6; pp. 647 - 656 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Nov2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140250548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140250548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Nov2019 vid: 54 iid: 6 pid: 622 pub: Oxford University Press / USA artinfo: ui: 140250548 140250548 140250548 10.1093/alcalc/agz069 140250548 ppf: 647 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Different Characteristics and Heritabilities of Alcohol Use Disorder Classes: A Population-Based Swedish Study. aug: au: Long, E C Ohlsson, H Sundquist, J Sundquist, K Kendler, K S affil: Edna Bennett Pierce Prevention Research Center, Pennsylvania State University, 314 Biobehavioral Health Building, University Park, PA 16802, USA sug: subj: Alcohol Abuse Familial and Genetic Substance Use Disorders Sweden Drinking Behavior Human Descriptive Statistics Sweden Latent Structure Analysis Alcohol Abuse Complications Comorbidity Crime Male Female Outpatients Inpatients Interpersonal Relations Record Review Male Female ab: Aims The aims of the present study are to identify alcohol use disorder (AUD) classes among a population-based Swedish sample, determine if these classes differ by variables known to be associated with AUD and determine whether some AUD classes have stronger genetic influences than others. Methods A latent class analysis (LCA), based on types of registrations, was conducted on Swedish individuals with an AUD registration born between 1960 and 1990 (N = 184,770). These classes were then validated using demographics; patterns of comorbidity with drug abuse, psychiatric disorders and criminal behavior; and neighborhood-level factors, i.e. peer AUD and neighborhood deprivation. The degree of genetic and environmental influence was also investigated. Results The best-fit LCA had four classes: (a) outpatient/prescription, characterized by a mix of outpatient medical and prescription registrations, (b) low-frequency inpatient, characterized entirely by inpatient medical registrations, with the majority of individuals having one AUD registration, (c) high-frequency mixed, characterized by a mix of all four registration types, with the majority having four or more registrations and (d) crime, characterized almost entirely by criminal registrations. The highest heritability for both males and females was found for Class 3 (61% and 65%, respectively) and the lowest for Class 1 (20% for both), with shared environmental influences accounting for 10% or less of the variance in all Classes. Conclusions Using comprehensive, nationwide registry data, we showed evidence for four distinct, meaningful classes of AUD with varying degrees of heritability. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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