The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori-Positive Patients.
Background and Aim. As a worldwide infectious bacterium, H. pylori leads to stomach pathologies such as gastritis, peptic ulcer, gastric cancer, MALToma, and various extragastric manifestations. In our study, we aimed to investigate the association between serum vitamin B12 level and cytotoxin-assoc...
| Publicado en: | BioMed Research International pp. 1 - 6 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/9/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140267476&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140267476 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/9/2019 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 140267476 140267476 140267476 10.1155/2019/1450536 140267476 ppf: 1 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori-Positive Patients. aug: au: Ulasoglu, Celal Temiz, Hatice Esin Sağlam, Zuhal Aydan affil: Department of Gastroenterology, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey sug: subj: Helicobacter Infections Diagnosis Cytotoxins Blood Virulence Vitamin B12 Deficiency Risk Factors Stomach Diseases Risk Factors Risk Assessment Human Immunoglobulins Blood Endoscopy Methods Female Male Histological Techniques Lymphocytes Dyspepsia Diagnosis Metaplasia Diagnosis Atrophy Diagnosis Lymphoid Tissue Analysis Female Male ab: Background and Aim. As a worldwide infectious bacterium, H. pylori leads to stomach pathologies such as gastritis, peptic ulcer, gastric cancer, MALToma, and various extragastric manifestations. In our study, we aimed to investigate the association between serum vitamin B12 level and cytotoxin-associated gene-A (CagA) seropositivity, which is one of the virulence factors of Helicobacter pylori (H. pylori). Method. This study has been conducted on 289 patients who have met the inclusion criteria. Within these patients, 213 of them were H. pylori positive and 76 were negative. Vitamin B12 and CagA-IgG levels were assessed in consecutive dyspeptic patients undergoing upper endoscopy. Results. Out of 289 patients, 51.9% were women (n = 150) and H. pylori was detected in 213 (73.7%) patients. Histopathological evaluation with modified Sydney classification revealed lymphocyte infiltration in 66.8% (n = 193), activation in 46% (n = 133), metaplasia in 11.4% (n = 33), atrophy in 11.4% (n = 33), and lymphoid follicles in 21.1% (n = 61) of the patients. Within H. pylori-positive patients, the ratio of CagA positivity was 57.3% (n = 122). Low B12 vitamin level was significantly correlated with existence of H. pylori (p=0.02), CagA (p=0.002), lymphocyte (p=0.006), metaplasia (p=0.001), atrophy (p=0.001), and lymphoid follicles (p=0.006). Positivity of CagA has been detected to be statistically corelated with lymphocyte (p=0.001) and activation (p=0.005); however, the same relation was not present with atrophy (p=0.236). Conclusion. In conclusion, B12 deficiency was positively correlated with CagA positivity and gastric inflammatory activity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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