Connectometry evaluation in patients undergoing carotid endarterectomy: an exploratory study.
This research investigated local brain connectivity changes following Carotid Endarterectomy (CEA) by connectometry. Seventeen subjects (15 males and 2 females, mean age 74.1 years), all eligible for CEA, were prospectively recruited in this exploratory study. On the same day within the week before...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 6; pp. 1708 - 1719 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140292627&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140292627 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2019 vid: 13 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 140292627 140292627 NLM30535626 140292627 10.1007/s11682-018-0024-9 NLM30535626 140292627 ppf: 1708 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Connectometry evaluation in patients undergoing carotid endarterectomy: an exploratory study. aug: au: Porcu, Michele Craboledda, Davide Garofalo, Paolo Columbano, Giulio Barberini, Luigi Sanfilippo, Roberto Zaccagna, Fulvio Wintermark, Max Montisci, Roberto Saba, Luca affil: Department of Radiology, University Hospital of Cagliari, Cagliari, Italy sug: subj: Brain Brain Physiopathology Brain Mapping Endarterectomy, Carotid Aged Prospective Studies Magnetic Resonance Imaging Female Telencephalon Male Human Scales Aged: 65+ years Female Male ab: This research investigated local brain connectivity changes following Carotid Endarterectomy (CEA) by connectometry. Seventeen subjects (15 males and 2 females, mean age 74.1 years), all eligible for CEA, were prospectively recruited in this exploratory study. On the same day within the week before the CEA, each patient underwent a cognitive evaluation with a Mini Mental State Examination (MMSE) and a Magnetic Resonance Imaging (MRI) exam that included a DTI sequence for the connectometry analysis. A second MMSE and the same MRI protocol were performed on follow-up, 3-6 months after CEA. The MMSE scores were analyzed using T-Student tests. The connectometry analysis was performed using a multiple regression model to consider the effect of CEA, choosing three different T-score threshold (T-threshold) values (1, 2 and 3). Results were considered statistically valid for p value adjusted for False Discovery Rate (p-FDR) < 0.05. Comparison of pre-CEA and post-CEA MMSE scores showed improvement of MMSE scores after CEA. Connectometry analysis revealed no areas of statistically significant increased connectivity related to CEA for T-threshold value = 1 and 2, but showed statistically significant increase of connectivity after CEA in both cerebellar hemispheres and corpus callosum for T-threshold value = 3 (p-FDR = 0.0106667). The network property analysis showed improved small worldness (2.14%), clustering coefficient (1.64%), local (1.94%) and global efficiency (0.56%), and reduced characteristic path length (-0.52%) after CEA. These results suggest that CEA is associated both with cognitive performance improvement and changes in interhemispheric local connectivity in the corpus callosum and cerebellum. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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