Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults.
Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51-78 years)....
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 6; pp. 1602 - 1612 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140292641&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140292641 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2019 vid: 13 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 140292641 140292641 NLM31209835 140292641 10.1007/s11682-019-00144-1 NLM31209835 140292641 ppf: 1602 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults. aug: au: Garcia-Egan, Paola M. Preston-Campbell, Rebecca N. Salminen, Lauren E. Heaps-Woodruff, Jodi M. Balla, Lila Cabeen, Ryan P. Laidlaw, David H. Conturo, Thomas E. Paul, Robert H. affil: Department of Psychological Sciences, University of Missouri, 63121, St. Louis, MO, USA sug: subj: Brain Nerve Fibers Brain Anatomy and Histology Aged Male Task Performance and Analysis Neuropsychological Tests Female Telencephalon Neural Pathways Reaction Time Magnetic Resonance Imaging Limbic System Middle Age Funding Source Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51-78 years). Participants underwent neuroimaging with 3 Tesla MRI, and completed a behavioral test of inhibition (i.e., Go/NoGo task). Quantitative tractography derived from diffusion tensor imaging (qtDTI) was used to measure white matter fiber bundle lengths (FBLs) in tracts known to innervate frontal brain regions, including the anterior corpus callosum (AntCC), the cingulate gyrus segment of the cingulum bundle (CING), uncinate fasciculus (UNC), and the superior longitudinal fasciculus (SLF). Performance on the Go/NoGo task was measured by the number of commission errors standardized to reaction time. Hierarchical regression models revealed that shorter FBLs in the CING (p < 0.05) and the bilateral UNC (p < 0.01) were associated with lower inhibitory performance after adjusting for multiple comparisons, supporting a disconnection model of response inhibition in older adults. Prospective longitudinal studies are needed to examine the evolution of inhibitory errors in older adult populations and potential for therapeutic intervention. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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