Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia.
Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 6; pp. 1746 - 1756 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140292643&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140292643 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2019 vid: 13 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 140292643 140292643 NLM31327125 140292643 10.1007/s11682-019-00160-1 NLM31327125 140292643 ppf: 1746 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia. aug: au: Cai, Wanye Zhao, Meng Liu, Jingjing Liu, Bo Yu, Dahua Yuan, Kai affil: School of Life Science and Technology, Xidian University, 710071, Xi'an, Shanxi, People's Republic of China sug: subj: Brain Pathology Insomnia Pathology Brain Nerve Fibers Pathology Insomnia Diagnosis Adult Neural Pathways Pathology Male Female Magnetic Resonance Imaging Funding Source Human Scales Adult: 19-44 years Male Female ab: Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate fasciculus (Arc) and superior longitudinal fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p < 0.01). Axial diffusivity (AD) for PI patients was higher in right Arc and lower in right SLF. Correlation analyses revealed that FA of right Arc and MD of right SLF were negatively correlated with PSQI score in PI patients, and AD of right Arc and FA of right SLF were positively correlated with PSQI score. Negative correlation was observed between FA of right Arc and AD of right SLF and ISI score in PI patients. Our findings can help us to improve the understanding of the neural mechanisms of primary insomnia at abnormalities in WM microstructure. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|