Episodic memory for visual scenes suggests compensatory brain activity in breast cancer patients: a prospective longitudinal fMRI study.
It has been hypothesized that breast cancer and its chemotherapy can impart functional neural changes via an overlap with biological mechanisms associated with aging. Here we used fMRI to assess whether changes in neural activity accompanying visual episodic memory encoding and retrieval suggest alt...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 6; pp. 1674 - 1689 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140292646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140292646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2019 vid: 13 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 140292646 140292646 NLM30680610 140292646 10.1007/s11682-019-00038-2 NLM30680610 140292646 ppf: 1674 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Episodic memory for visual scenes suggests compensatory brain activity in breast cancer patients: a prospective longitudinal fMRI study. aug: au: Pergolizzi, Denise Root, James C. Pan, Hong Silbersweig, David Stern, Emily Passik, Steven D. Ahles, Tim A. affil: Department of Psychiatry and Behavioral Sciences, Sloan Kettering Institute for Cancer Research, 641 Lexington Avenue, 7th Floor, 10022, New York, NY, USA sug: subj: Brain Brain Physiopathology Breast Neoplasms Physiopathology Memory Magnetic Resonance Imaging Middle Age Prospective Studies Chemotherapy, Adjuvant Female Clinical Assessment Tools Impact of Events Scale Funding Source Middle Aged: 45-64 years Female ab: It has been hypothesized that breast cancer and its chemotherapy can impart functional neural changes via an overlap with biological mechanisms associated with aging. Here we used fMRI to assess whether changes in neural activity accompanying visual episodic memory encoding and retrieval suggest altered activations according to patterns seen in functional imaging of cognitive aging. In a prospective longitudinal design, breast cancer patients (n = 13) were scanned during memory encoding and retrieval before and after chemotherapy treatment, and compared to healthy-age matched controls (n = 13). Our results indicate that despite equivalent behavioral performance, encoding and retrieval resulted in increased activation of prefrontal regions for the breast cancer group compared to controls for both before and after chemotherapy treatment. This was accompanied by decreased activity in posterior brain regions after chemotherapy, particularly those involved in visual processing, for the breast cancer group compared to controls. These findings are discussed as evidence for a possible anterior shift in neural processing to compensate for deficiencies in posterior brain regions, consistent with an accelerated aging account. Cancer and chemotherapy can impact brain regions underlying episodic memory, leading to additional recruitment of control regions, which may be linked to mechanisms related to aging. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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