Mapping anticipatory anhedonia: an fMRI study.
Anhedonia-broadly defined as loss of interest and/or an inability to experience pleasure-is an important feature of several psychiatric disorders. Research into the clinical presentation and neurobiology of this symptom has identified components related to motivation, learning, anticipation, and exp...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 6; pp. 1624 - 1635 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140292649&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140292649 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2019 vid: 13 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 140292649 140292649 NLM31030316 140292649 10.1007/s11682-019-00084-w NLM31030316 140292649 ppf: 1624 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mapping anticipatory anhedonia: an fMRI study. aug: au: Szczepanik, Joanna E. Reed, Jessica L. Nugent, Allison C. Ballard, Elizabeth D. Evans, Jennifer W. Lejuez, Carl W. Zarate, Carlos A. Zarate, Carlos A Jr affil: Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA sug: subj: Reward Learning Brain Mapping Magnetic Resonance Imaging Anhedonia Telencephalon Physiology Male Adult Female Motivation Limbic System Physiology Reaction Time Physiology Human Funding Source Adult: 19-44 years Male Female ab: Anhedonia-broadly defined as loss of interest and/or an inability to experience pleasure-is an important feature of several psychiatric disorders. Research into the clinical presentation and neurobiology of this symptom has identified components related to motivation, learning, anticipation, and experience of pleasure as important constructs that inform therapeutic interventions. The experimental study of anhedonia is largely based on incentive processing paradigms, most often with monetary rewards, though studies have also used pleasantness ratings of various stimuli. However, linking an individual's own system of reinforcers and ability to enjoy them with anhedonia and neural activity remains comparatively under-explored. A previous study of participants with major depressive disorder (MDD) and healthy controls found that activity word ratings correlated with measures of anhedonia, depression, and motivation. The present study collected functional magnetic resonance imaging (fMRI) images in healthy controls while they rated activity words and pictures showing activities in order to identify networks differentially responsive to subjective decisions about the appetitive value of activities. The study sought to measure individually-relevant hedonic capacity as demonstrated by correlations between task measures and anticipatory anhedonia ratings. Ratings of potential pleasure were associated with neural activity in areas previously identified as relevant to pleasure and reward processing, such as anterior and posterior cingulate, middle frontal areas, and dorsal and ventral striatum. Although the study included only healthy controls, the results demonstrate a link between anhedonia measures, behavior, and brain responses and also test a paradigm that could be used to study anhedonia in clinical populations. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|