Connectivity and morphology of hubs of the cerebral structural connectome are associated with brain resilience in AD- and age-related pathology.
The physiological basis of resilience to age-associated and AD-typical neurodegenerative pathology is still not well understood. So far, the established resilience factor intelligence has been shown to be associated with white matter network global efficiency, a key constituent of which are highly c...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 6; pp. 1650 - 1665 |
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| Autores principales: | , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140292650&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140292650 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2019 vid: 13 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 140292650 140292650 NLM30980275 140292650 10.1007/s11682-019-00090-y NLM30980275 140292650 ppf: 1650 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Connectivity and morphology of hubs of the cerebral structural connectome are associated with brain resilience in AD- and age-related pathology. aug: au: Fischer, Florian U. Wolf, Dominik Fellgiebel, Andreas affil: Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany sug: subj: Alzheimer's Disease Pathology Cerebral Cortex Pathology Aging Brain Pathology Brain Mapping Female Male Image Processing, Computer Assisted Brain Physiology Cognition Magnetic Resonance Imaging Aged Gray Matter Pathology Tomography, Emission-Computed Brain Nervous System Pathology Cerebral Cortex Physiopathology Human Aged: 65+ years Female Male ab: The physiological basis of resilience to age-associated and AD-typical neurodegenerative pathology is still not well understood. So far, the established resilience factor intelligence has been shown to be associated with white matter network global efficiency, a key constituent of which are highly connected hubs. However, hub properties have also been shown to be impaired in AD. Individual predisposition or vulnerability of hub properties may thus modulate the impact of pathology on cognitive outcome and form part of the physiological basis of resilience. 85 cognitively normal elderly subjects and patients with MCI with DWI, MRI and AV45-PET scans were included from ADNI. We reconstructed the global WM networks in each subject and characterized hub-properties of GM regions using graph theory by calculating regional betweenness centrality. Subsequently, we investigated whether regional GM volume (GMV) and structural WM connectivity (WMC) of more hub-like regions was more associated with resilience, quantified as cognitive performance independent of amyloid burden, tau and WM lesions. Subjects with higher resilience showed higher increased regional GMV and WMC in more hub-like compared to less hub-like GM-regions. Additionally, this association was in some instances further increased at elevated amounts of brain pathology. Higher GMV and WMC of more hub-like regions may contribute more to resilience compared to less hub-like regions, reflecting their increased importance to brain network efficiency, and may thus form part of the neurophysiological basis of resilience. Future studies should investigate the factors leading to higher GMV and WMC of hubs in non-demented elderly with higher resilience. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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