miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2.
Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents with a poor prognosis. Though miR-509-5p has been reported as a tumor suppressor in several human cancers, the role of miR-509-5p in OS remains unclear. In this study, our result of real-time PCR (RT-PCR) showed that th...
| Publicado en: | BioMed Research International pp. 1 - 13 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/16/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=140476973&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 140476973 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/16/2019 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 140476973 140476973 140476973 10.1155/2019/2523032 140476973 ppf: 1 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2. aug: au: Guo, Jiekun Wu, Qiang Peng, Xiaoming Yu, Bin affil: Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China sug: subj: MicroRNA Metabolism Gene Expression Cell Line, Tumor Metabolism Cell Proliferation Neoplasm Invasiveness Prevention and Control Osteosarcoma Prevention and Control Protein Kinases Metabolism Polymerase Chain Reaction Methods MicroRNA Analysis Human Genes, Tumor Suppressor Cell Physiology ab: Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents with a poor prognosis. Though miR-509-5p has been reported as a tumor suppressor in several human cancers, the role of miR-509-5p in OS remains unclear. In this study, our result of real-time PCR (RT-PCR) showed that the expression of miR-509-5p was significantly decreased in OS tissues and cell lines. Overexpression of miR-509-5p significantly suppressed cell proliferation and invasion in OS cell lines. Moreover, we identified tribbles homolog 2 (TRIB2) as the direct target of miR-509-5p. Knockdown of TRIB2 could inhibit the malignant capacity of OS cells. At last, we reported that TRIB2 could inhibit the bioactivity of the tumor suppressor gene p21 via blocking its transcriptional activity. Collectively, our study revealed that miR-509-5p functions as a tumor suppressor by targeting TRIB2 in OS and thus could affect the activity of p21, suggesting that miR-509-5p is a novel preventive intervention for OS patients. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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