Kidney and organoid single-cell transcriptomics: the end of the beginning.
Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just the last year, multiple scRNA-seq datasets have been generated from kidney organoids, developing mouse and human kidney, adult kidney, and ki...
| Publicado en: | Pediatric Nephrology Vol. 35; no. 2; pp. 191 - 198 |
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| Autores principales: | , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141003305&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141003305 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Feb2020 vid: 35 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141003305 141003305 141003305 10.1007/s00467-018-4177-y 141003305 ppf: 191 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Kidney and organoid single-cell transcriptomics: the end of the beginning. aug: au: Wilson, Parker C. Humphreys, Benjamin D. affil: Department of Pathology and Immunology, Washington University in Saint Louis School of Medicine, 660. S Euclid Ave., CB 8118, St. Louis, MO, USA sug: subj: Kidney Diseases Physiopathology Stem Cells Analysis Gene Expression Profiling Sequence Analysis Methods Bioinformatics Allografts Graft Rejection Cytological Techniques Genetic Techniques Biological Phenomena ab: Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just the last year, multiple scRNA-seq datasets have been generated from kidney organoids, developing mouse and human kidney, adult kidney, and kidney cancer. The data generated enables a much deeper understanding of biological processes within and between cells. It has also elucidated unforeseen cell lineage relationships, defined the presence of off-target cell types in kidney organoids, and revealed a diverse inflammatory response in a human kidney allograft undergoing rejection. This review summarizes the recent rapid progress in scRNA-seq of the kidney and outlines future directions for single-cell technologies as applied to the kidney. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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