Diagnostic accuracy of fetal MRI to detect cleft palate: a meta-analysis.
This systematic review aims to determine the diagnostic accuracy of fetal MRI for detecting cleft palate in fetuses at risk for orofacial clefts. Pubmed, Embase, and CINAHL were searched systematically. A diagnostic study was included if it performed MRI (index test) and postnatal examination (refer...
| Publicado en: | European Journal of Pediatrics Vol. 179; no. 1; pp. 29 - 39 |
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| Autores principales: | , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141049156&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141049156 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03406199 CR1 jtl: European Journal of Pediatrics issn: 03406199 maglogo: N pubinfo: dt: Jan2020 vid: 179 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141049156 141049156 NLM31797081 141049156 10.1007/s00431-019-03500-x NLM31797081 141049156 ppf: 29 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diagnostic accuracy of fetal MRI to detect cleft palate: a meta-analysis. aug: au: van der Hoek-Snieders, Hanneke E. M. van den Heuvel, Antonius J. M. L. van Os-Medendorp, Harmieke Kamalski, Digna M. A. affil: Clinical Health Sciences, Faculty of Medicine, Utrecht University, Utrecht, The Netherlands sug: subj: Prenatal Diagnosis Methods Magnetic Resonance Imaging Cleft Palate Human Pregnancy Female Sensitivity and Specificity Meta Analysis Systematic Review Female ab: This systematic review aims to determine the diagnostic accuracy of fetal MRI for detecting cleft palate in fetuses at risk for orofacial clefts. Pubmed, Embase, and CINAHL were searched systematically. A diagnostic study was included if it performed MRI (index test) and postnatal examination (reference test) in fetuses at risk for orofacial clefts. Methodological quality was assessed using the QUADAS-2. A meta-analysis was performed with a random-effects model, calculating the pooled sensitivity, specificity, and area under the curve. The search resulted in eight studies (334 fetuses) to be included: four prospective and four retrospective studies. The applicability concern was low. There was, however, a risk of selection and information bias. All studies showed that MRI well predicted the chance of cleft palate. The sensitivity results were homogeneous, but heterogeneity was assumed regarding the specificity estimate (Cochrane's Q test: p = 0.00). The pooled sensitivity was 0.97 (95% CI 0.93-0.99); the pooled specificity was 0.94 (0.89-0.97). The area under the curve was 0.98 (95% CI 0.98-0.99).Conclusion: This meta-analysis shows that MRI has an excellent sensitivity and good to excellent specificity for diagnosing cleft palate in fetuses at risk for orofacial clefts. Future research should assess applicability for clinical care.What is Known:• Using ultrasound for prenatal detection of cleft palate leads to misdiagnosis frequently.• MRI could potentially improve the prenatal detection rate of cleft palate.What is New:• Eight studies describe the diagnostic accuracy of MRI for detecting cleft palate.• Combined results show excellent sensitivity and good to excellent specificity. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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