CT and MR imaging findings of the livers in adults with Fontan palliation: an observational study.
Purpose: To describe liver imaging findings and complications on computed tomography (CT) or magnetic resonance imaging (MRI) in adults with Fontan palliation and investigate whether imaging features show correlations with clinical and physiological parameters. Methods: Our Institutional Review Boar...
| Publicado en: | Abdominal Radiology Vol. 45; no. 1; pp. 188 - 203 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141078430&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141078430 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jan2020 vid: 45 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141078430 10.1007/s00261-019-02119-8 141078430 ppf: 188 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: CT and MR imaging findings of the livers in adults with Fontan palliation: an observational study. aug: au: Yang, Hyun Kyung Jang, Hyun-Jung Khalili, Korosh Wald, Rachel M. Yoo, Shi-Joon Kim, Tae Kyoung affil: Joint Department of Medical Imaging, Toronto General Hospital, University of Toronto, 585 University Avenue, M5G 2N2, Toronto, ON, Canada sug: ab: Purpose: To describe liver imaging findings and complications on computed tomography (CT) or magnetic resonance imaging (MRI) in adults with Fontan palliation and investigate whether imaging features show correlations with clinical and physiological parameters. Methods: Our Institutional Review Board approved this retrospective study. Two blinded abdominal radiologists reviewed abdominal CT (n = 21) and MRI (n = 16) images between September 2011 and October 2017 in 37 adults (median age 27 years, interquartile range 21–36 years, 14 males [38%]) with a Fontan palliation (median post-Fontan duration 22 years, interquartile range 19–28 years). Correlation between CT/MRI findings and clinical parameters including laboratory results within 6 months of CT/MRI examinations was assessed by Spearman's rank correlation coefficient. Results: Lobulated hepatic surface and blunt hepatic edge were seen in 92% (34/37) and 95% (35/37) of patients, respectively. Surface nodularity was noted in 32% (12/37). In 7 patients, there were 11 hepatic nodules which showed arterial-phase hyperenhancement and washout. Among them, 2 were biopsy-proven hepatocellular carcinomas (HCCs), and the remaining 9 were focal nodular hyperplasia (FNH)-like nodules. Suprahepatic inferior vena cava (IVC) diameter showed positive correlations with post-Fontan duration (p < 0.01), serum gamma-glutamyl transferase (p < 0.01), and total bilirubin (p < 0.01). Conclusion: The livers in post-Fontan adults show a unique morphology of blunt edge and lobulating surface with occasional nodularity. There is a diagnostic challenge in distinguishing HCCs from FNH-like nodules in post-Fontan population due to overlapping imaging findings. Suprahepatic IVC diameter is a potentially useful imaging marker that reflects hepatic dysfunction in Fontan palliation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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