Hepatocyte fraction: correlation with noninvasive liver functional biomarkers.
Purpose: To evaluate the correlation between HeF obtained from gadoxetic acid-enhanced MR imaging and clinical biomarkers for the assessment of liver function. Methods: This prospective study was approved by our Institutional Review Board, and written informed consent was obtained from the patients....
| Publicado en: | Abdominal Radiology Vol. 45; no. 1; pp. 83 - 90 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141078444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141078444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jan2020 vid: 45 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141078444 10.1007/s00261-019-02238-2 141078444 ppf: 83 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hepatocyte fraction: correlation with noninvasive liver functional biomarkers. aug: au: Noda, Yoshifumi Goshima, Satoshi Okuaki, Tomoyuki Akamine, Yuta Kajita, Kimihiro Kawai, Nobuyuki Kawada, Hiroshi Tanahashi, Yukichi Matsuo, Masayuki affil: Department of Radiology, Gifu University, 1-1 Yanagido, 501-1194, Gifu, Japan sug: ab: Purpose: To evaluate the correlation between HeF obtained from gadoxetic acid-enhanced MR imaging and clinical biomarkers for the assessment of liver function. Methods: This prospective study was approved by our Institutional Review Board, and written informed consent was obtained from the patients. We recruited 48 patients carrying a known or suspected liver disease to undergo gadoxetic acid-enhanced MR imaging. The new model of the HeF was calculated from ΔR1 values of the liver and spleen. The HeF, quantitative liver-to-spleen contrast ratio (Q-LSC), and ΔT1 value (the reduction rate of the T1 value between the pre- and post-contrast images) were compared with the Child–Pugh and end-stage liver disease (MELD) scores. Results: Among 48 patients, 40 were in Child–Pugh class A and 8 were in class B. The median HeF (P = 0.0001), Q-LSC (P = 0.015), and ΔT1 value (P = 0.0023) in patients in Child–Pugh class A were significantly higher than those in class B. The sensitivities, specificities, and area under the receiver-operating-characteristic curves for differentiating Child–Pugh class A and B were 95.0%, 87.5%, and 0.93 in the HeF; 77.5%, 75.0%, and 0.78 in the Q-LSC; and 57.5%, 100.0%, and 0.84 in the ΔT1 value, respectively. The HeF was significantly correlated with Child–Pugh (r = − 0.58, P < 0.0001) and MELD score (r = − 0.57, P < 0.0001). Conclusions: The HeF was well correlated with Child–Pugh and MELD score and could be a new biomarker to assess liver function. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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