Intravoxel incoherent motion imaging for diagnosing and staging the liver fibrosis and inflammation.
Purpose: To evaluate the diagnostic accuracy of intravoxel incoherent motion (IVIM) model parameters for the diagnosis and staging of liver fibrosis and inflammation in patients with chronic hepatitis B. Methods: Fifty-four patients with chronic hepatitis B and 42 healthy volunteers were included in...
| Publicado en: | Abdominal Radiology Vol. 45; no. 1; pp. 15 - 24 |
|---|---|
| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141078456&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141078456 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jan2020 vid: 45 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141078456 10.1007/s00261-019-02300-z 141078456 ppf: 15 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Intravoxel incoherent motion imaging for diagnosing and staging the liver fibrosis and inflammation. aug: au: Tosun, Mesude Onal, Tugay Uslu, Hande Alparslan, Burcu Çetin Akhan, Sıla affil: Department of Radiology, Kocaeli University School of Medicine, Kocaeli, Turkey sug: ab: Purpose: To evaluate the diagnostic accuracy of intravoxel incoherent motion (IVIM) model parameters for the diagnosis and staging of liver fibrosis and inflammation in patients with chronic hepatitis B. Methods: Fifty-four patients with chronic hepatitis B and 42 healthy volunteers were included in the study. All subjects were examined by 3 T magnetic resonance imaging. Diffusion-weighted imaging was undertaken with sixteen b values. IVIM parameters [D (true diffusion coefficient), D* (pseudo-diffusion coefficient), f (perfusion fraction)] were calculated. Histological evaluation of biopsy samples was considered the reference standard for the staging of liver fibrosis and inflammation. Differences in IVIM parameters between patient and control groups were analyzed. In the patient group, fibrosis stage and inflammation grade groups were analyzed with respect to IVIM parameters. The correlation was assessed between IVIM parameters and Ishak-modified scale of fibrosis stages and inflammation grades. Results: The D was significantly lower in the patient group than the control group, p = 0.038 with Cohen's d effect size of 0.452. D was significantly different between fibrosis stage levels. D values decreased in fibrosis stages from the minimal to moderate to marked fibrosis. Fibrosis grades significantly negatively correlated with D and D* values, p = 0.001, and 0.021, respectively. In addition, inflammation grades negatively correlated with f values, p = 0.047. Conclusion: D values measured with IVIM imaging may help to diagnose liver fibrosis. IVIM imaging could be an alternative to liver biopsy for the staging of liver fibrosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|