Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis.
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is one of the top ten infectious diseases worldwide, and is the leading cause of morbidity from a single infectious agent. M. tuberculosis can cause infection in several species of animals in addition to humans as the nat...
| Publicado en: | BioMed Research International pp. 1 - 23 |
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| Autores principales: | , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
1/8/2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141095209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141095209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/8/2020 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 141095209 141095209 141095209 10.1155/2020/4263079 141095209 ppf: 1 ppct: 22 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Animal Models of Tuberculosis Vaccine Research: An Important Component in the Fight against Tuberculosis. aug: au: Gong, Wenping Liang, Yan Wu, Xueqiong affil: Heishanhu Road, Haidian District, Beijing 100091, China sug: subj: Tuberculosis Prevention and Control Models, Biological Bacterial Vaccines Research, Medical Mice Guinea Pigs Goats Cattle Mycobacterium Tuberculosis Primates ab: Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is one of the top ten infectious diseases worldwide, and is the leading cause of morbidity from a single infectious agent. M. tuberculosis can cause infection in several species of animals in addition to humans as the natural hosts. Although animal models of TB disease cannot completely simulate the occurrence and development of human TB, they play an important role in studying the pathogenesis, immune responses, and pathological changes as well as for vaccine research. This review summarizes the commonly employed animal models, including mouse, guinea pig, rabbit, rat, goat, cattle, and nonhuman primates, and their characteristics as used in TB vaccine research, and provides a basis for selecting appropriate animal models according to specific research needs. Furthermore, some of the newest animal models used for TB vaccine research (such as humanized animal models, zebrafish, Drosophila, and amoeba) are introduced, and their characteristics and research progress are discussed. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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