Assessment of primary liver carcinomas other than hepatocellular carcinoma (HCC) with LI-RADS v2018: comparison of the LI-RADS target population to patients without LI-RADS-defined HCC risk factors.
Objectives: To determine whether the LI-RADS imaging features of primary liver carcinomas (PLCs) other than hepatocellular carcinoma (non-HCC PLCs) differ between patients considered high risk (RF+) versus not high risk (RF-) for HCC and to compare rates of miscategorization as probable or definite...
| Published in: | European Radiology Vol. 30; no. 2; pp. 996 - 1008 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Feb2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141192336&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141192336 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2020 vid: 30 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141192336 141192336 NLM31654212 141192336 10.1007/s00330-019-06448-6 NLM31654212 141192336 ppf: 996 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Assessment of primary liver carcinomas other than hepatocellular carcinoma (HCC) with LI-RADS v2018: comparison of the LI-RADS target population to patients without LI-RADS-defined HCC risk factors. aug: au: Fraum, Tyler J. Cannella, Roberto Ludwig, Daniel R. Tsai, Richard Naeem, Muhammad LeBlanc, Maverick Salter, Amber Tsung, Allan Shetty, Anup S. Borhani, Amir A. Furlan, Alessandro Fowler, Kathryn J. affil: Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8131, 510 S. Kingshighway Blvd, 63110, Saint Louis, MO, USA sug: subj: Carcinoma, Hepatocellular Liver Neoplasms Middle Age Magnetic Resonance Imaging Methods Logistic Regression Single-Blind Studies Contrast Media Human Female Tomography, X-Ray Computed Methods Retrospective Design Risk Factors Male Liver Neoplasms Pathology Carcinoma, Hepatocellular Pathology Diagnosis, Differential Aged Validation Studies Comparative Studies Evaluation Research Multicenter Studies Psychological Tests Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objectives: To determine whether the LI-RADS imaging features of primary liver carcinomas (PLCs) other than hepatocellular carcinoma (non-HCC PLCs) differ between patients considered high risk (RF+) versus not high risk (RF-) for HCC and to compare rates of miscategorization as probable or definite HCC between the RF+ and RF- populations.Methods: This retrospective study included all pathology-proven non-HCC PLCs imaged with liver-protocol CT or MRI from 2007 to 2017 at two liver transplant centers. Patients were defined per LI-RADS v2018 criteria as RF+ or RF-. Two independent, blinded readers (R1, R2) categorized 265 lesions using LI-RADS v2018. Logistic regression was utilized to assess for differences in imaging feature frequencies between RF+ and RF- patients. Fisher's exact test was used to assess for differences in miscategorization rates.Results: Non-HCC PLCs were significantly more likely to exhibit nonrim arterial phase hyperenhancement (R1: OR = 2.94; R2: OR = 7.09) and nonperipheral "washout" (R1: OR = 3.65; R2: OR = 7.69) but significantly less likely to exhibit peripheral "washout" (R1: OR = 0.30; R2: OR = 0.10) and delayed central enhancement (R1: OR = 0.18; R2: OR = 0.25) in RF+ patients relative to RF- patients. Consequently, non-HCC PLCs were more often miscategorized as probable or definite HCC in RF+ versus RF- patients (R1: 23.3% vs. 3.6%, p < 0.001; R2: 11.0% vs. 2.6%, p = 0.009).Conclusions: Non-HCC PLCs are more likely to mimic HCCs on CT and MRI in the LI-RADS target population than in patients without LI-RADS-defined HCC risk factors.Key Points: • The presence of LI-RADS-defined risk factors for HCC tends to alter the imaging appearances of non-HCC PLCs, resulting in higher frequencies of major features and lower frequencies of LR-M features. • Non-HCC PLCs are more likely to be miscategorized as probable or definite HCC in the LI-RADS target population than in patients without LI-RADS-defined HCC risk factors. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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