Therapeutic efficacy of the combination therapy of corticosteroids and 5-aminosalicylic acid for treatment of pyoderma gangrenosum with ulcerative colitis.
Background: Pyoderma gangrenosum (PG) in inflammatory bowel disease (IBD) is a rare cutaneous condition and its treatment remains controversial due to limited data. Aims and Objectives: The purpose of this study was to investigate the characteristics and treatment response to specific therapies of I...
| Publicado en: | Indian Journal of Dermatology Vol. 65; no. 1; pp. 38 - 42 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Jan/Feb2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141208096&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141208096 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00195154 259H jtl: Indian Journal of Dermatology issn: 00195154 maglogo: N pubinfo: dt: Jan/Feb2020 vid: 65 iid: 1 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 141208096 141208096 141208096 10.4103/ijd.IJD_505_18 141208096 ppf: 38 ppct: 4 formats: tig: atl: Therapeutic efficacy of the combination therapy of corticosteroids and 5-aminosalicylic acid for treatment of pyoderma gangrenosum with ulcerative colitis. aug: au: Chen, Wei Xiang, Lijuan Li, Li affil: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu sug: subj: Adrenal Cortex Hormones Therapeutic Use Mesalamine Therapeutic Use Drug Therapy, Combination Colitis, Ulcerative Complications Pyoderma Gangrenosum Etiology Pyoderma Gangrenosum Drug Therapy Colitis, Ulcerative Drug Therapy Human Treatment Outcomes Retrospective Design Male Female Pyoderma Gangrenosum Diagnosis Colitis, Ulcerative Diagnosis Immunoglobulins, Intravenous Therapeutic Use Infliximab Therapeutic Use Cyclophosphamide Therapeutic Use Male Female ab: Background: Pyoderma gangrenosum (PG) in inflammatory bowel disease (IBD) is a rare cutaneous condition and its treatment remains controversial due to limited data. Aims and Objectives: The purpose of this study was to investigate the characteristics and treatment response to specific therapies of IBD-associated PG. Methods: In this retrospective study, we reviewed a series of cases of IBD-associated PG patients who presented at our institution, and collected clinical data, such as demographics, characteristics, subtype, and disease activity of IBD and specific therapies used and their treatment response. Results: In total, 42 cases were identified: 69% female and 92.9% with ulcerative colitis (UC). At PG diagnosis, 93% had active and 7% inactive IBD. PG ulcers occurred predominantly on the legs (33.3%); 14.3% had multiple lesions. In total, 20/39 UC patients received the combination therapy of systemic corticosteroids and 5-aminosalicylic acid (5-ASA) with a good response in 19 patients (95%). Seven patients received the monotherapy of 5-ASA with a response rate of 43%. Five patients were successfully treated with systemic corticosteroids alone. Other patients were treated with intravenous immunoglobulin, infliximab, or cyclophosphamide alone or in combination with corticosteroids and all showed a good response. Conclusion: Our study indicates the therapeutic efficacy of corticosteroids in combination with 5-ASA, which may be considered as the first-line therapy for UC-associated PG. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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