Epigenetic studies and pediatric research.
The 2020 Annual Review Issue, "Preventing Disease in the 21st Century" was selected by the Editors-in-Chief of Pediatric Research to include a variety of disease entities that confront health-care practitioners entrusted to the care of infants and children. In keeping with this mandate, this article...
| Publicado en: | Pediatric Research Vol. 87; no. 2; pp. 378 - 385 |
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| Autor principal: | |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Jan2020
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141210146&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141210146 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00313998 4FF jtl: Pediatric Research issn: 00313998 maglogo: N pubinfo: dt: Jan2020 vid: 87 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 141210146 141210146 NLM31731288 141210146 10.1038/s41390-019-0644-9 NLM31731288 141210146 ppf: 378 ppct: 7 formats: tig: atl: Epigenetic studies and pediatric research. aug: au: Bellanti, Joseph A. affil: Departments of Pediatrics and Microbiology-Immunology, Georgetown University Medical Center, Washington, DC, USA sug: subj: Genomics Research, Medical Genes Pediatrics Metabolism Animals RNA Metabolism DNA Methylation RNA Fetal Development Proteins Scales ab: The 2020 Annual Review Issue, "Preventing Disease in the 21st Century" was selected by the Editors-in-Chief of Pediatric Research to include a variety of disease entities that confront health-care practitioners entrusted to the care of infants and children. In keeping with this mandate, this article reviews the subject of epigenetics, which impacts pediatric research from bench to bedside. Epigenetic mechanisms exert their effects through the interaction of environment, various susceptibility genes, and immunologic development and include: (1) DNA methylation; (2) posttranslational modifications of histone proteins through acetylation and methylation, and (3) RNA-mediated gene silencing by microRNA (miRNA) regulation. The effects of epigenetics during fetal life and early periods of development are first reviewed together with clinical applications of cardiovascular and metabolic disorders in later life. The relationships of epigenetics to the allergic and autoimmune diseases and cancer are next reviewed. A specific focus of the article is directed to the recent recognition that many of these disorders are driven by aberrant immune responses in which immunoregulatory events are often poorly functioning and where through interventive epigenetic measures prevention may be possible by alterations in programming of DNA during fetal and early periods as well as in later life. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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