Atrial septum biopsy for direct substrate characterization in atrial fibrillation.
Introduction: The aim of this study was to describe and illustrate the technique of performing interatrial septum biopsy and to demonstrate its use for direct histological substrate characterization in atrial fibrillation (AF). Methods and Results: Biopsies were performed in four patients who underw...
| Published in: | Journal of Cardiovascular Electrophysiology Vol. 31; no. 1; pp. 308 - 313 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
Jan2020
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141251929&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141251929 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10453873 GSB jtl: Journal of Cardiovascular Electrophysiology issn: 10453873 maglogo: Y pubinfo: dt: Jan2020 vid: 31 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 141251929 141251929 141251929 10.1111/jce.14308 141251929 ppf: 308 ppct: 5 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Atrial septum biopsy for direct substrate characterization in atrial fibrillation. aug: au: Sepehri Shamloo, Alireza Husser, Daniela Buettner, Petra Klingel, Karin Hindricks, Gerhard Bollmann, Andreas affil: Department of Electrophysiology, Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute, Leipzig Germany sug: subj: Heart Septal Defects, Atrial Pathology Biopsy Methods Atrial Fibrillation Surgery Histological Techniques Atrial Septum Human Catheter Ablation Fibrosis Inflammation Histology Echocardiography, Transesophageal ab: Introduction: The aim of this study was to describe and illustrate the technique of performing interatrial septum biopsy and to demonstrate its use for direct histological substrate characterization in atrial fibrillation (AF). Methods and Results: Biopsies were performed in four patients who underwent AF catheter ablation. Bipal 7 bioptome was directed through a steerable sheath directly onto the septum. Fluoroscopic views as well as echocardiography‐guided techniques were utilized to confirm that the tip was oriented towards the interatrial septum. The bioptome was then placed on the right atrial (RA) septum and maneuvered to obtain the specimens (at least 1 mm in size) from the posterior septal region of the RA, adjacent to the fossa ovalis. Bioptome placement and sample acquisition were successful in all patients at the first attempt. No patient developed any minor or major complications during the procedure and hospital stay. All the biopsy specimens had proper qualities for histological assessments and revealed a variety of pathologies including fibrosis, inflammation, and fatty infiltration. Conclusion: Atrial septum biopsies could be safely performed guided by fluoroscopy and transesophageal echocardiography. The obtained specimens allowed for a detailed localized substrate characterization which is of great interest in AF. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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