Multicentre study on dynamic contrast computed tomography findings of focal liver lesions with clinical and histological correlation.
Background: Current advancements in dynamic contrast imaging of the liver have enabled increased sensitivity in the diagnosis of liver lesions. Evaluation and characterisation of the enhancement pattern of liver lesions in respect to the liver parenchyma aids in making a specific diagnosis. Objectiv...
| Published in: | South African Journal of Radiology Vol. 23; no. 1; pp. 1 - 8 |
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| Main Authors: | , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
African Online Scientific Information System PTY LTD
2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141255559&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141255559 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1027202X 39WP jtl: South African Journal of Radiology issn: 1027202X maglogo: N pubinfo: dt: 2019 vid: 23 iid: 1 pid: 56831 pub: African Online Scientific Information System PTY LTD place: , <Blank> artinfo: ui: 141255559 141255559 141255559 10.4102/sajr.v23i1.1667 141255559 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Multicentre study on dynamic contrast computed tomography findings of focal liver lesions with clinical and histological correlation. aug: au: Ominde, Sheila T. Mutala, Timothy M. affil: Department of Diagnostic Imaging and Radiation Medicine, University of Nairobi, Nairobi, Kenya sug: subj: Tomography, X-Ray Computed Methods Liver Diseases Radiography Histological Techniques Liver Diseases Pathology Human Multicenter Studies Prospective Studies Cross Sectional Studies Radiologists Biopsy Methods Data Analysis Software Carcinoma, Hepatocellular Radiography Predictive Value of Tests Sensitivity and Specificity Validity ab: Background: Current advancements in dynamic contrast imaging of the liver have enabled increased sensitivity in the diagnosis of liver lesions. Evaluation and characterisation of the enhancement pattern of liver lesions in respect to the liver parenchyma aids in making a specific diagnosis. Objectives: The aim of this study was to determine the liver findings on dynamic contrast computed tomography (CT) scanning and correlate them with clinicopathologic findings. Methods: This prospective cross-sectional study included 61 patients and took place between August 2017 and February 2018. Dynamic contrast CT was performed and the images were evaluated by two experienced radiologists. Correlation of the CT findings with histology results from an ultrasound-guided biopsy was done. Data analysis was performed using SPSS version 20.0. Results: Hepatocellular carcinoma (HCC) was the most common malignant lesion seen and showed three patterns of enhancement: homogenous, abnormal internal vessels and heterogeneous enhancement. Abnormal internal vessel pattern was most specific (90.6%) and showed a high positive predictive value (PPV) of 78.6%. Rapid washout showed a specificity of 87.5% and a PPV of 72.2% in the diagnosis of HCC. Dynamic contrast CT scan had a sensitivity of 93%, specificity of 50%, PPV of 91% and diagnostic accuracy of 95.5% in differentiation of benign and malignant liver lesions. Considering only Liver Imaging Reporting and Data System (LI-RADS) category 5 as conclusive for HCC diagnosis, our study did not miss a significant number of HCCs. Liver Imaging Reporting and Data System category 5 showed specificity of 81.3% and PPV of 75%. Conclusion: Enhancement patterns on a dynamic contrast CT scan of the liver are useful in the interpretation of CT images for specific diagnoses. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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