B-Type Natriuretic Peptides (BNP) and Tissue Doppler E/e´ Before and After 4 Weeks Standard Treatment of African Heart Failure Subjects: The ABU-BNP Longitudinal Survey.
Background: The study aimed at determining the response of BNP and tissue Doppler (TD) E/e´ to standard heart failure (HF) therapy in an African black population as data on these are lacking in Africa. BNP assessment in relation to HF severity and its association with its predictors were also determ...
| Publicado en: | Vascular Health & Risk Management Vol. 15; pp. 559 - 570 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Dove Medical Press Ltd
Dec2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=141287627&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 141287627 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11766344 6BXM jtl: Vascular Health & Risk Management issn: 11766344 maglogo: N pubinfo: dt: Dec2019 vid: 15 pid: 45064 pub: Dove Medical Press Ltd place: Auckland, <Blank> artinfo: ui: 141287627 141287627 NLM31908467 10.2147/VHRM.S211498 NLM31908467 141287627 ppf: 559 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: B-Type Natriuretic Peptides (BNP) and Tissue Doppler E/e´ Before and After 4 Weeks Standard Treatment of African Heart Failure Subjects: The ABU-BNP Longitudinal Survey. aug: au: Onyemelukwe, Obiageli Uzoamaka Oyati, Albert Imhoagene Danbauchi, Solomon Sulei Obasohan, Austine sug: subj: Mitral Valve Echocardiography, Doppler, Pulsed Natriuretic Peptide, Brain Blood Heart Failure Therapy Black Persons Ventricular Function, Left Reproducibility of Results Middle Age Severity of Illness Indices Male Heart Failure Blood Female Prospective Studies Treatment Outcomes Predictive Value of Tests Mitral Valve Physiopathology Heart Failure Ethnology Time Factors Nigeria Heart Failure Adult Clinical Assessment Tools Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Background: The study aimed at determining the response of BNP and tissue Doppler (TD) E/e´ to standard heart failure (HF) therapy in an African black population as data on these are lacking in Africa. BNP assessment in relation to HF severity and its association with its predictors were also determined.Methods: It was a longitudinal-analytical study with a one month follow-up among 100 HF patients seen at Ahmadu Bello University Teaching Hospital, Zaria-Nigeria. Two-way Repeated Measures ANOVA determined BNP levels before and after treatment according to the HF severity. Wilcoxon-Signed Ranks test determined the difference in BNP and TD E/e´ before and after treatment. Pearson's correlation assessed log-transformed BNP's association with its predictors.Results: BNP significantly (p<0.001) rose with increasing severity of HF from 386.6 ± 186.5 pg/mL to 581.7 ± 299.0 pg/mL to 805.0 ± 484.0 pg/mL in the NYHA II-IV HF, respectively, with consequent fall in a similar fashion following treatment. The Median (IQR) BNP levels reduced significantly (p<0.001) from 450 (362.5, 712.5) to 275.0 (225, 375.2) pg/mL with a 38.9% reduction over 4 weeks associated with significant improvement in TD E/e´, structural and functional parameters. Ln10BNP was significantly (p<0.001) positively correlated to TD E/e´ before (r=0.51) and after treatment (r=0.43). Likewise, Ln10BNP was significantly (p<0.05) negatively correlated to ejection fraction & fractional shortening before and after treatment.Conclusion: BNP and tissue Doppler can serve as useful tools in the assessment of the effectiveness of African HF treatment and functional capacity over 4 weeks. TD E/e´ may be a reliable non-invasive estimate of left ventricular filling pressures and diastolic dysfunction. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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